| Item type |
文献 / Documents(1) |
| 公開日 |
2018-10-17 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.2152/jmi.65.242 |
|
|
関連名称 |
10.2152/jmi.65.242 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis |
| タイトル別表記 |
|
|
その他のタイトル |
Wild grape alleviates nasal symptoms. |
| 著者 |
Islam, Rezwanul
水口, 博之
Shaha, Aurpita
ニシダ, コウヘイ
ヤブモト, マサミ
イケダ, ヒサシ
藤野, 裕道
北村, 嘉章
福井, 裕行
武田, 憲昭
|
| 抄録 |
|
|
内容記述 |
As expression level of allergic disease-sensitive genes are correlated with allergic symptom severity, suppression of these gene expressions could be good therapeutics. We have demonstrated that PKCδ signaling and NFAT signaling, involve in histamine H1 receptor (H1R) and IL-9 gene expressions, respectively, are responsible for the pathogenesis of allergic rhinitis. We explore anti-allergic compounds that suppress these signaling pathways and found that wild grape (WG) contains such compounds. Here, we investigated the effect of WG hot water extract (WGE) on the signaling pathways for PKCδ-mediated H1R and NFAT-mediated IL-9 gene expressions. WGE suppressed histamine/PMA-induced H1R gene up-regulation in HeLa cells. Toluene-2,4-diisocyanate (TDI)-induced H1R mRNA elevation in TDI-sensitized rats was also suppressed by WGE treatment. Treatment with WGE in combination with Awa-tea, suppresses NFAT signaling-mediated IL-9 gene, markedly alleviated nasal symptoms. Furthermore, WGE suppressed PMA-induced IL-33 gene up-regulation in Swiss 3T3 cells. Data suggest that combination of WGE, suppresses PKCδ signaling with Awa-tea, suppresses NFAT signaling would have distinct clinical and therapeutic advantages as a substitute for anti-allergic drugs. In addition, as the expression level of IL-33 mRNA was correlated with the blood eosinophils number in patients with pollinosis, WG could alleviate eosinophilic inflammation through the suppression of IL-33 gene expression. |
| キーワード |
|
|
主題 |
Allergic rhinitis |
| キーワード |
|
|
主題 |
histamine H1 receptor |
| キーワード |
|
|
主題 |
Interleukin-33 |
| キーワード |
|
|
主題 |
nuclear factor of activated T-cells |
| キーワード |
|
|
主題 |
protein kinase Cδ |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 65,
号 3-4,
p. 242-250,
発行日 2018-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Faculty of Medicine Tokushima University |
| EID |
|
|
識別子 |
353060 |
| 言語 |
|
|
言語 |
eng |
jmi_65_3-4_242.pdf (306 KB)
