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Differentiation of preadipocytes and mature adipocytes requires PSMB8
https://tokushima-u.repo.nii.ac.jp/records/2005470
https://tokushima-u.repo.nii.ac.jp/records/200547007a33a4b-9a3e-42d5-910b-60d6e064c46d
| 名前 / ファイル | ライセンス | アクション |
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srep_6_26791.pdf (1.16 MB)
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srep_6_26791_s1.pdf (734 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2018-11-12 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/srep26791 | |||||||||||||||||
| 関連名称 | 10.1038/srep26791 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Differentiation of preadipocytes and mature adipocytes requires PSMB8 | |||||||||||||||||
| 著者 |
有持, 秀喜
× 有持, 秀喜
WEKO
1616
× 佐々木, 由紀× 北村, 明子× 安友, 康二
WEKO
1521
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| 抄録 | ||||||||||||||||||
| 内容記述 | The differentiation of adipocytes is tightly regulated by a variety of intrinsic molecules and also by extrinsic molecules produced by adjacent cells. Dysfunction of adipocyte differentiation causes lipodystrophy, which impairs glucose and lipid homeostasis. Although dysfunction of immunoproteasomes causes partial lipodystrophy, the detailed molecular mechanisms remain to be determined. Here, we demonstrate that Psmb8, a catalytic subunit for immunoproteasomes, directly regulates the differentiation of preadipocytes and additionally the differentiation of preadipocytes to mature adipocytes. Psmb8−/− mice exhibited slower weight gain than wild-type mice, and this was accompanied by reduced adipose tissue volume and smaller size of mature adipocytes compared with controls. Blockade of Psmb8 activity in 3T3-L1 cells disturbed the differentiation to mature adipocytes. Psmb8−/− mice had fewer preadipocyte precursors, fewer preadipocytes and a reduced ability to differentiate preadipocytes toward mature adipocytes. Our data demonstrate that Psmb8-mediated immunoproteasome activity is a direct regulator of the differentiation of preadipocytes and their ultimate maturation. | |||||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 6, p. 26791, 発行日 2016-05-26 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||
| 備考 | ||||||||||||||||||
| 値 | Supplementary Information : srep_6_26791_s1.pdf | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 316697 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
