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Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model
https://tokushima-u.repo.nii.ac.jp/records/2005523
https://tokushima-u.repo.nii.ac.jp/records/200552336bc608e-b598-4ef9-b6b2-3ee1dc225a22
| 名前 / ファイル | ライセンス | アクション |
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cas_108_9_1864.pdf (568 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||
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| 公開日 | 2018-11-12 | |||||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1111/cas.13305 | |||||||||||||||||||||||||||||||
| 関連名称 | 10.1111/cas.13305 | |||||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||
| タイトル | Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model | |||||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||||
| その他のタイトル | Immunomodulation effect of liposomal oxaliplatin | |||||||||||||||||||||||||||||||
| 著者 |
清水, 太郎
× 清水, 太郎× Lila, Amr S. Abu
× ニシオ, ミホ
× ドイ, ユウスケ
× 安藤, 英紀
WEKO
700
× 鵜川, 真実× 異島, 優× 石田, 竜弘
WEKO
1145
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| 内容記述 | Immune modulation of the tumor microenvironment has been reported to participate in the therapeutic efficacy of many chemotherapeutic agents. Recently, we reported that liposomal encapsulation of oxaliplatin (l-OHP) within PEGylated liposomes conferred a superior antitumor efficacy to free l-OHP in murine colorectal carcinoma-bearing mice through permitting preferential accumulation of the encapsulated drug within tumor tissue. However, the contribution of the immune-modulatory properties of liposomal l-OHP and/or free l-OHP to the overall antitumor efficacy was not elucidated. In the present study, therefore, we investigated the effect of liposomal encapsulation of l-OHP within PEGylated liposomes on the antitumor immunity in both immunocompetent and immunodeficient mice. Liposomal l-OHP significantly suppressed the growth of tumors implanted in immunocompetent mice, but not in immunodeficient mice. In immunocompetent mice, liposomal l-OHP increased the tumor MHC-1 level and preserved antitumor immunity through decreasing the number of immune suppressor cells, including regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages, which collectively suppress CD8+ T cell-mediated tumor cells killing. In contrast, free l-OHP ruined antitumor immunity. These results suggest that the antitumor efficacy of liposomal l-OHP is attributed, on the one hand, to its immunomodulatory effect on tumor immune microenvironment that is superior to that of free l-OHP, and on the other hand, to its direct cytotoxic effect on tumor cells. | |||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||
| 主題 | Antitumor immunity | |||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||
| 主題 | drug delivery system | |||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||
| 主題 | immunomodulation | |||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||
| 主題 | liposome | |||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||
| 主題 | oxaliplatin | |||||||||||||||||||||||||||||||
| 書誌情報 |
en : Cancer Science 巻 108, 号 9, p. 1864-1869, 発行日 2017-06-23 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||
| 収録物識別子 | 13497006 | |||||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||||
| 出版者 | Japanese Cancer Association | |||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||
| 権利情報 | © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
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| EID | ||||||||||||||||||||||||||||||||
| 識別子 | 325157 | |||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||
