| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-12 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-017-07341-2 |
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関連名称 |
10.1038/s41598-017-07341-2 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions |
| 著者 |
ワタナベ, リュウイチ
フジタ, ノブユキ
サトウ, ユイコ
コバヤシ, タミ
モリタ, マユ
オイケ, タカツグ
ミヤモト, カナ
クロオ, マコト
ミチガミ, トシミ
福本, 誠二
ツジ, タカシ
トヤマ, ヨシアキ
ナカムラ, マサヤ
マツモト, モリオ
ミヤモト, タケシ
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| 抄録 |
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内容記述 |
Control of phosphate metabolism is crucial to regulate aging in mammals. Klotho is a well-known anti-aging factor that regulates phosphate metabolism: mice mutant or deficient in Klotho exhibit phenotypes resembling human aging. Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) is required for Klotho expression under phosphate overload conditions. Loss-of-function Enpp1 ttw/ttw mice under phosphate overload conditions exhibited phenotypes resembling human aging and Klotho mutants, such as short life span, arteriosclerosis and osteoporosis, with elevated serum 1,25(OH)2D3 levels. Enpp1ttw/ttw mice also exhibited significantly reduced renal Klotho expression under phosphate overload conditions, and aging phenotypes in these mice were rescued by Klotho overexpression, a low vitamin D diet or vitamin D receptor knockout. These findings indicate that Enpp1 plays a crucial role in regulating aging via Klotho expression under phosphate overload conditions. |
| 書誌情報 |
en : Scientific Reports
巻 7,
p. 7786,
発行日 2017-08-10
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20452322 |
| 出版者 |
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出版者 |
Springer Nature |
| 備考 |
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|
値 |
Supplementary Figures : srep_7_7786_s1.pdf |
| 権利情報 |
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|
権利情報 |
© The Author(s) 2017 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
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識別子 |
334749 |
| 言語 |
|
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言語 |
eng |
srep_7_7786.pdf (2.04 MB)
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