| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2018-11-12 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-018-20185-8 |
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関連名称 |
10.1038/s41598-018-20185-8 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Zika virus infection elicits auto-antibodies to C1q |
| 著者 |
駒, 貴明
Veljkovic, Veljko
Anderson, Danielle E.
Wang, Lin-Fa
Rossi, Shannan L.
Shan, Chao
Shi, Pei-Yong
Beasley, David W.
Bukreyeva, Natalya
Smith, Jeanon N.
Hallam, Steven
Huang, Cheng
von Messling, Veronika
Paessler, Slobodan
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| 抄録 |
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内容記述 |
Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barré syndrome and thrombocytopenia have also been reported. To determine which host factors are related to pathogenesis, the E protein of ZIKV was analyzed with the Informational Spectrum Method, which identifies common information encoded by primary structures of the virus and the respective host protein. The data showed that the ZIKV E protein and the complement component C1q cross-spectra are characterized by a single dominant peak at the frequency F = 0.338, suggesting similar biological properties. Indeed, C1q-specific antibodies were detected in sera obtained from mice and monkeys infected with ZIKV. As C1q has been known to be involved not only in immunity, but also in synaptic organization and different autoimmune diseases, a ZIKV-induced anti-C1q antibody response may contribute to the neurological complications. These findings might also be exploited for the design of safe and efficacious vaccines in the future. |
| 書誌情報 |
en : Scientific Reports
巻 8,
p. 1882,
発行日 2018-01-30
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20452322 |
| 出版者 |
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出版者 |
Springer Nature |
| 備考 |
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値 |
Dataset : srep_8_1882_s1.xlsx |
| 権利情報 |
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権利情報 |
© The Author(s) 2018 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
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識別子 |
337756 |
| 言語 |
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言語 |
eng |
srep_8_1882.pdf (1.9 MB)
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srep_8_1882_s1.xlsx (25.9 KB)
