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Potential Role of Free Fatty Acids in the Pathogenesis of Periodontitis and Primary Sjögren's Syndrome
https://tokushima-u.repo.nii.ac.jp/records/2005558
https://tokushima-u.repo.nii.ac.jp/records/2005558a8cf06e9-d3eb-4cc4-91ad-ebf870d75ed3
| 名前 / ファイル | ライセンス | アクション |
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ijms_18_4_836.pdf (566 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2018-11-12 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/ijms18040836 | |||||||||||||||||||||||
| 関連名称 | 10.3390/ijms18040836 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Potential Role of Free Fatty Acids in the Pathogenesis of Periodontitis and Primary Sjögren's Syndrome | |||||||||||||||||||||||
| 著者 |
四釜, 洋介
× 四釜, 洋介× 工藤, 保誠
WEKO
572
× 石丸, 直澄
WEKO
1721
× 船木, 真理
WEKO
337
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| 内容記述 | Clinical studies have shown that metabolic disorders such as type 2 diabetes and dyslipidemia are associated with increased risk of oral-related diseases, such as periodontitis and Sjögren’s syndrome. Although changes in the immune system are critical in both of these metabolic disorders and oral-related diseases, the mechanism underlying the interaction between these diseases remains largely unknown. Obesity and type 2 diabetes are known to be associated with higher concentrations of free fatty acids in blood. Among free fatty acids, saturated fatty acids such as palmitic acid have been demonstrated to induce inflammatory responses mainly via the innate immune systems, and to be involved in the pathogenesis of type 2 diabetes in tissues such as adipose tissue, liver, pancreas, and skeletal muscle. Here, we highlight recent advances in evidence for the potential involvement of palmitic acid in the pathogenesis of periodontitis and Sjögren’s syndrome, and discuss the possibility that improvement of the lipid profile could be a new strategy for the treatment of these diseases. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | periodontitis | |||||||||||||||||||||||
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| 主題 | Sjögren’s syndrome | |||||||||||||||||||||||
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| 主題 | free fatty acid | |||||||||||||||||||||||
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| 主題 | type 2 diabetes | |||||||||||||||||||||||
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| 主題 | metabolic disorder | |||||||||||||||||||||||
| 書誌情報 |
en : International Journal of Molecular Sciences 巻 18, 号 4, p. 836, 発行日 2017-04-14 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 14220067 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 16616596 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA12038549 | |||||||||||||||||||||||
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| 出版者 | MDPI | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||
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| 識別子 | 326918 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
