| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-12 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/ncomms10351 |
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言語 |
ja |
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関連名称 |
10.1038/ncomms10351 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells |
|
言語 |
en |
| 著者 |
オオゾネ, チカフミ
スガ, ヒデタカ
エイラク, モトツグ
カドシマ, タイスケ
米村, 重信
タカタ, ノゾム
オオイソ, ユタカ
ツジ, タカシ
ササイ, ヨシキ
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and negative regulators are indispensable for homeostasis. For this reason, generating human anterior pituitary tissue that retains regulatory hormonal control in vitro is an important step for the development of cell transplantation therapy for pituitary diseases. Here we achieve this by recapitulating mouse pituitary development using human embryonic stem cells. We find that anterior pituitary self-forms in vitro following the co-induction of hypothalamic and oral ectoderm. The juxtaposition of these tissues facilitated the formation of pituitary placode, which subsequently differentiated into pituitary hormone-producing cells. They responded normally to both releasing and feedback signals. In addition, after transplantation into hypopituitary mice, the in vitro-generated corticotrophs rescued physical activity levels and survival of the hosts. Thus, we report a useful methodology for the production of regulator-responsive human pituitary tissue that may benefit future studies in regenerative medicine. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 7,
p. 10351,
発行日 2016-01-14
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20411723 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
Supplementary Information : ncomms_7_10351_s1.pdf
Supplementary movies : ncomms_7_10351_s2.mov, ncomms_7_10351_s3.mov |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
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|
識別子 |
315722 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ncomms_7_10351.pdf (2.12 MB)
.png)
ncomms_7_10351_s2.mov (11.1 MB)
