| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-12 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/srep44522 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1038/srep44522 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model |
|
言語 |
en |
| 著者 |
オオノ, ミツアキ
大島, 正充
オガワ, ミホ
ソノヤマ, ワタル
ハラ, エミリオ サトシ
オイダ, ヤスタカ
シンカワ, シゲヒコ
ナカジマ, リュウ
ミネ, アツシ
ハヤノ, サトル
フクモト, サトシ
カスガイ, ショウヘイ
ヤマグチ, アキラ
ツジ, タカシ
クボキ, タクオ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model. Herein, we demonstrate functional tooth restoration through the autologous transplantation of bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, which was reconstructed using permanent tooth germ cells, erupted into the jawbone after autologous transplantation and achieved physiological function equivalent to that of a natural tooth. This study represents a substantial advancement in whole-organ replacement therapy through the transplantation of bioengineered organ germ as a practical model for future clinical regenerative medicine. |
|
言語 |
en |
| 書誌情報 |
en : Scientific Reports
巻 7,
p. 44522,
発行日 2017-03-16
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20452322 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
Supplemental Information : srep_7_44522_s1.pdf |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
|
|
識別子 |
341547 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
srep_7_44522.pdf (1.66 MB)
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