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Renoprotective effects of a factor Xa inhibitor : fusion of basic research and a database analysis
https://tokushima-u.repo.nii.ac.jp/records/2005594
https://tokushima-u.repo.nii.ac.jp/records/200559411b2e2b5-0e6a-4f2c-a338-bff2d449045c
| 名前 / ファイル | ライセンス | アクション |
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srep_8_10858.pdf (1.49 MB)
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srep_8_10858_s1.pdf (247 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2018-11-12 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-018-29008-2 | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 関連名称 | 10.1038/s41598-018-29008-2 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Renoprotective effects of a factor Xa inhibitor : fusion of basic research and a database analysis | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 著者 |
堀ノ内, 裕也
× 堀ノ内, 裕也
× 池田, 康将× 福島, 圭穣× 今西, 正樹× 濱野, 裕章× (井澤)石澤, 有紀× 座間味, 義人× 武智, 研志
× 宮本, 理人× 藤野, 裕道× 石澤, 啓介× 土屋, 浩一郎× 玉置, 俊晃 |
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Renal tubulointerstitial injury, an inflammation-associated condition, is a major cause of chronic kidney disease (CKD). Levels of activated factor X (FXa), a blood coagulation factor, are increased in various inflammatory diseases. Therefore, we investigated the protective effects of an FXa inhibitor against renal tubulointerstitial injury using unilateral ureteral obstruction (UUO) mice (a renal tubulointerstitial fibrosis model) and the Food and Drug Administration Adverse Events Reporting System (FAERS) database. The renal expression levels of FX and the FXa receptors protease-activated receptor (PAR)-1 and PAR-2 were significantly higher in UUO mice than in sham-operated mice. UUO-induced tubulointerstitial fibrosis and extracellular matrix expression were suppressed in UUO mice treated with the FXa inhibitor edoxaban. Additionally, edoxaban attenuated UUO-induced macrophage infiltration and inflammatory molecule upregulation. In an analysis of the FAERS database, there were significantly fewer reports of tubulointerstitial nephritis for patients treated with FXa inhibitors than for patients not treated with inhibitors. These results suggest that FXa inhibitors exert protective effects against CKD by inhibiting tubulointerstitial fibrosis. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 8, p. 10858, 発行日 2018-07-18 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 備考 | ||||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 値 | Supplementary Figure : srep_8_10858_s1.pdf | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | © The Author(s) 2018 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 342025 | |||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
