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Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse
https://tokushima-u.repo.nii.ac.jp/records/2005597
https://tokushima-u.repo.nii.ac.jp/records/200559777a425c6-9cab-4b14-aead-a3ca6f781e0e
| 名前 / ファイル | ライセンス | アクション |
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ncomms_7_13391.pdf (5.57 MB)
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ncomms_7_13391_s1.pdf (467 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2018-11-12 | |||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/ncomms13391 | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 関連名称 | 10.1038/ncomms13391 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 著者 |
イマガワ, ユウスケ
× イマガワ, ユウスケ
× 齊藤, 達哉× ツジモト, ヨシヒデ
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| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Programmed cell death has a crucial role in various biological events, including developmental morphogenesis. Recent evidence indicates that necrosis contributes to programmed cell death in addition to apoptosis, but it is unclear whether necrosis acts as a compensatory mechanism for failure of apoptosis or has an intrinsic role during development. In contrast to apoptosis, there have been no techniques for imaging physiological necrosis in vivo. Here we employ vital staining using propidium iodide to identify cells with plasma membrane disruption (necrotic cells) in mouse embryos. We discover a form of necrosis at the bone surface, which does not occur in embryos with deficiency of the autophagy-related gene Atg9a, although it is unaffected by Atg5 knockout. We also find abnormalities of the bone surface in Atg9a knockout mice, suggesting an important role of Atg9a-dependent necrosis in bone surface formation. These findings suggest that necrosis has an active role in developmental morphogenesis. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Nature Communications 巻 7, p. 13391, 発行日 2016-11-04 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 20411723 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA12645905 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 備考 | ||||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 値 | Supplementary Information : ncomms_7_13391_s1.pdf | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||
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| 識別子 | 323024 | |||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
