| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-07 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.ijdevneu.2016.05.003 |
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関連名称 |
10.1016/j.ijdevneu.2016.05.003 |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Developmental changes in the hypothalamic mRNA expression levels of PACAP and its receptor PAC1 and their sensitivity to fasting in male and female rats |
| 著者 |
岩佐, 武
松崎, 利也
Tungalagsuvd, Altankhuu
Munkhzaya, Munkhsaikhan
Mayila, Yiliyasi
加藤, 剛志
桑原, 章
苛原, 稔
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| 抄録 |
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内容記述 |
The actions and responses of hypothalamic appetite regulatory and factors change markedly during the neonatal to pre-pubertal period. Pituitary adenylate cyclase-activating polypeptide (PACAP) has been found to play pivotal roles in the regulation of metabolic and nutritional status through its specific receptor PAC1. PACAP/PAC1 have anorectic roles, and their functions are regulated by leptin in adulthood. In the present study, we showed that hypothalamic PACAP mRNA expression decreases during the neonatal to pre-pubertal period (from postnatal day 10 to 30) in both male and female rats. During this period, hypothalamic PACAP mRNA expression was not affected by 24 h fasting in either sex, while the serum leptin levels (leptin is a positive regulator of hypothalamic PACAP expression in adulthood) of both sexes were decreased by fasting. On the other hand, hypothalamic PAC1 mRNA expression did not change during the neonatal to pre-pubertal period in either sex; however, its levels were consistently higher in males than in females. Hypothalamic PAC1 mRNA expression was decreased by 24 h fasting in males, but no such changes were observed in females. These results indicate while hypothalamic PACAP expression is sensitive to a negative energy state and the serum leptin level in adulthood, no such relationships are seen in the pre-pubertal period. In addition, we speculate that differences in the gonadal steroidal milieu might induce sexual dimorphism in the basal hypothalamic PAC1 mRNA level and its response to fasting. The mechanisms responsible for and the physiological effects of such changes in hypothalamic PACAP and PAC1 expression during the developmental period remain to be clarified. |
| キーワード |
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主題 |
PACAP |
| キーワード |
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主題 |
PAC1 |
| キーワード |
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主題 |
Leptin |
| キーワード |
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|
主題 |
Hypothalamus |
| 書誌情報 |
en : International Journal of Developmental Neuroscience
巻 52,
p. 33-37,
発行日 2016-05-12
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
07365748 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10637655 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11531026 |
| 出版者 |
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出版者 |
Elsevier |
| 権利情報 |
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|
権利情報 |
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| EID |
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|
識別子 |
328267 |
| 言語 |
|
|
言語 |
eng |
ijdevneu_52_33.pdf (206 KB)
