| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-07 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.yhbeh.2017.05.008 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.yhbeh.2017.05.008 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
The effects of chronic testosterone administration on body weight, food intake, and adipose tissue are changed by estrogen treatment in female rats |
|
言語 |
en |
| 著者 |
岩佐, 武
松崎, 利也
矢野, 清人
ヤナギハラ, リエ
Tungalagsuvd, Altankhuu
Munkhzaya, Munkhsaikhan
Mayila, Yiliyasi
桑原, 章
苛原, 稔
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In females, estrogens play pivotal roles in preventing excess body weight (BW) gain. On the other hand, the roles of androgens in female BW, appetite, and energy metabolism have not been fully examined. We hypothesized that androgens’ effects on food intake (FI) and BW regulation change according to the estrogens’ levels. To evaluate this hypothesis, the effects of chronic testosterone administration in ovariectomized (OVX) female rats with or without estradiol supplementation were examined in this study. Chronic testosterone administration decreased BW, FI, white adipose tissue (WAT) weight, and adipocyte size in OVX rats, whereas it increased BW, WAT weight, and adipocyte size in OVX with estradiol-administered rats. In addition, chronic testosterone administration increased hypothalamic CYP19a1 mRNA levels in OVX rats, whereas it did not alter CYP19a1 mRNA levels in OVX with estradiol-administered rats, indicating that conversion of testosterone to estrogens in the hypothalamus may be activated in testosterone-administered OVX rats. Furthermore, chronic testosterone administration decreased hypothalamic TNF-α mRNA levels in OVX rats, whereas it increased hypothalamic IL-1β mRNA levels in OVX with estradiol-administered rats. On the other hand, IL-1β and TNF-α mRNA levels in visceral and subcutaneous WAT and liver were not changed by chronic testosterone administration in both groups. These data indicate that the effects of chronic testosterone administration on BW, FI, WAT weight, and adipocyte size were changed by estradiol treatment in female rats. Testosterone has facilitative effects on BW gain, FI, and adiposity under the estradiol-supplemented condition, whereas it has inhibitory effects in the non-supplemented condition. Differences in the responses of hypothalamic factors, such as aromatase and inflammatory cytokines, to testosterone might underlie these opposite effects. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Testosterone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Ovariectomy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hypothalamus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Il-1β |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TNF-α |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Leptin |
| 書誌情報 |
en : Hormones and Behavior
巻 93,
p. 53-61,
発行日 2017-05-17
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018506X |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00665370 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11539414 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| EID |
|
|
識別子 |
339208 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
hbeh_93_53.pdf (10.7 MB)
