| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-12 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/ncomms14229 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1038/ncomms14229 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features |
|
言語 |
en |
| 著者 |
セキ, リョウヘイ
Li, Cai
Fang, Qi
林, 真一
エガワ, シロウ
Hu, Jiang
Xu, Luohao
Pan, Hailin
コンドウ, マオ
サトウ, トモヒコ
マツバラ, ハルカ
カミヤマ, ナミコ
キタジマ, ケイイチ
サイトウ, ダイスケ
Liu, Yang
Gilbert, M. Thomas P.
Zhou, Qi
Xu, Xing
シロイシ, トシヒコ
イリエ, ナオキ
タムラ, コウジ
Zhang, Guojie
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers. By analysing 48 bird genomes, we identified millions of avian-specific highly conserved elements (ASHCEs) that predominantly (>99%) reside in non-coding regions. Many ASHCEs show differential histone modifications that may participate in regulation of limb development. Comparative embryonic gene expression analyses across tetrapod species suggest ASHCE-associated genes have unique roles in developing avian limbs. In particular, we demonstrate how the ASHCE driven avian-specific expression of gene Sim1 driven by ASHCE may be associated with the evolution and development of flight feathers. Together, these findings demonstrate regulatory roles of ASHCEs in the creation of avian-specific traits, and further highlight the importance of cis-regulatory rewiring during macroevolutionary changes. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 8,
p. 14229,
発行日 2017-02-06
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20411723 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
Supplementary Information : ncomms_8_14229_s1.pdf
Peer Review File : ncomms_8_14229_s3.pdf
DataSet 1 : ncomms_8_14229_s2.xlsx |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
|
|
識別子 |
341109 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ncomms_8_14229.pdf (1.72 MB)
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ncomms_8_14229_s2.xlsx (28.9 MB)
