| Item type |
文献 / Documents(1) |
| 公開日 |
2018-12-13 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1002/cbin.10692 |
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関連名称 |
10.1002/cbin.10692 |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells |
| タイトル別表記 |
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その他のタイトル |
Alkannin inhibits CCL3 and CCL5 production |
| 著者 |
細川, 義隆
細川, 育子
シンドウ, サトル
オオタ, ヨシヒロ
尾崎, 和美
松尾, 敬志
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| 抄録 |
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内容記述 |
Alkannin, which is found in Alkanna tinctoria, a member of the borage family, is used as a food coloring. Alkannin has recently been reported to have certain biological functions, such as anti-microbial and anti-oxidant effects. It is known that CC chemokine receptor (CCR) 5-positive leukocytes contribute to alveolar bone resorption in periodontal lesions. The aim of this study was to examine whether alkannin inhibits the production of CC chemokine ligand (CCL) 3 and CCL5, which are CCR5 ligands, in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CCL3 and CCL5 production in HPDLC. Alkannin inhibited IL-1β-mediated CCL3 and CCL5 production in HPDLC in a dose-dependent manner. Moreover, we revealed that alkannin suppressed inhibitor of kappa B-α degradation in IL-1β-stimulated HPDLC. In addition, a nuclear factor (NF)-κB inhibitor significantly inhibited CCL3 and CCL5 production in IL-1β-stimulated HPDLC. These results demonstrate that alkannin inhibits CCR5 ligand production in IL-1β-stimulated HPDLC by attenuating the NF-κB signaling pathway. |
| キーワード |
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主題 |
alkannin |
| キーワード |
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主題 |
CCL3 |
| キーワード |
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主題 |
CCL5 |
| キーワード |
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主題 |
NF‐κB |
| キーワード |
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主題 |
periodontal ligament cells |
| 書誌情報 |
en : Cell Biology International
巻 40,
号 12,
p. 1380-1385,
発行日 2016-10-24
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10656995 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10958355 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10882014 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11544414 |
| 出版者 |
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出版者 |
International Federation for Cell Biology |
| 出版者 |
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出版者 |
Wiley |
| 備考 |
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|
値 |
This is the peer reviewed version of the following article: Hosokawa, Y. , Hosokawa, I. , Shindo, S. , Ohta, Y. , Ozaki, K. and Matsuo, T. (2016), Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells. Cell Biol Int, 40: 1380-1385, which has been published in final form at https://doi.org/10.1002/cbin.10692.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| 権利情報 |
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|
権利情報 |
© 2016 International Federation for Cell Biology |
| EID |
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識別子 |
324808 |
| 言語 |
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言語 |
eng |
cbin_40_12_1380.pdf (342 KB)
