| Item type |
文献 / Documents(1) |
| 公開日 |
2018-12-13 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1080/08820139.2017.1336176 |
|
|
関連名称 |
10.1080/08820139.2017.1336176 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
IL-29 Enhances CXCL10 Production in TNF-α-stimulated Human Oral Epithelial Cells |
| タイトル別表記 |
|
|
その他のタイトル |
IL-29 enhances CXCL10 production |
| 著者 |
細川, 義隆
細川, 育子
シンドウ, サトル
尾崎, 和美
松尾, 敬志
|
| 抄録 |
|
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内容記述 |
Interleukin-29 (IL-29) is a cytokine belonging to the type III interferon family. It was recently detected in the gingival crevicular fluid of periodontitis patients. However, the role of IL-29 in the pathogenesis of periodontal disease remains unknown. The aim of this study was to examine the effects of IL-29 on C-X-C motif chemokine ligand 10 (CXCL10) production in human oral epithelial cells. We measured CXCL10 production in TR146 cells, which is a human oral epithelial cell line, using an enzyme-linked immunosorbent assay. We used Western blot analysis to detect IL-29 receptor expression and the phosphorylation levels of signal transduction molecules, including p38 mitogen-activated protein kinases (MAPK), signal transducer and activator of transcription 3 (STAT3), and nuclear factor (NF)-κB p65, in the TR146 cells. The TR146 cells expressed the IL-29 receptor. IL-29 induced CXCL10 production in the TR146 cells. IL-29 significantly enhanced CXCL10 production in tumor necrosis factor (TNF)-α-stimulated TR146 cells. The p38 MAPK, STAT3, and NF-κB pathways were found to be related to the IL-29-induced enhancement of CXCL10 production in TNF-α-stimulated TR146 cells. IL-29 promotes T helper 1 cell accumulation in periodontal lesions by inducing CXCL10 production in oral epithelial cells. |
| キーワード |
|
|
主題 |
CXCL10 |
| キーワード |
|
|
主題 |
IL-29 |
| キーワード |
|
|
主題 |
oral epithelial cells |
| 書誌情報 |
en : Immunological Investigations : A Journal of Molecular and Cellular Immunology
巻 46,
号 6,
p. 615-624,
発行日 2017-07-28
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
08820139 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15324311 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10519794 |
| 出版者 |
|
|
出版者 |
Taylor & Francis |
| 備考 |
|
|
値 |
This is an Accepted Manuscript of an article published by Taylor & Francis Group in Immunological Investigation on 28/07/2017, available online: http://www.tandfonline.com/10.1080/08820139.2017.1336176. |
| EID |
|
|
識別子 |
326882 |
| 言語 |
|
|
言語 |
eng |
imminv_ 46_6_ 615.pdf (382 KB)
