| Item type |
文献 / Documents(1) |
| 公開日 |
2019-01-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s41598-018-31464-9 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1038/s41598-018-31464-9 |
| 出版タイプ |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
|
|
タイトル |
An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
BMP4の機能調節は糖尿病性腎症及びポドサイト障害の治療につながる |
|
言語 |
ja |
| 著者 |
藤田, 結衣
冨永, 辰也
安部, 秀斉
カンガワ, ユミ
フクシマ, ナオシ
ウエダ, オトヤ
ジシャゲ, コウイチ
岸, 誠司
村上, 太一
サガ, ユミコ
Kanwar, Yashpal S.
長井, 幸二郎
土井, 俊夫
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Podocyte injury has been proposed to play an important role in diabetic nephropathy; however, its pathological mechanism remains unclear. We have shown that bone morphogenetic protein 4 (BMP4) signaling leads to the glomerular changes characteristic of this disorder. To analyze the molecular mechanism of podocyte injury, the effect of BMP4 was investigated using streptozotocin (STZ)- induced, Bmp4 heterozygous knockout (Bmp4+/−) and podocyte-specific Bmp4 knockout mice. Mice with STZ-induced diabetes exhibited glomerular matrix hyperplasia and decreased numbers of podocyte nucleus-specific WT1-positive cells. The number of podocytes and proteinuria were improved in both diabetic Bmp4 knockout mouse models compared to the effects observed in the control mice. The effect of BMP4 overexpression on Bmp4-induced or podocyte-specific transgenic mice was examined. Tamoxifen-induced Bmp4-overexpressing mice exhibited mesangial matrix expansion and decreased numbers of WT1-positive cells. Podocyte-specific Bmp4-overexpressing mice displayed increased kidney BMP4 expression and mesangial matrix expansion but decreased nephrin expression and numbers of WT1-positive cells. Both lines of Bmp4-overexpressing mice exhibited increased albuminuria. In cultured podocytes, BMP4 increased phospho-p38 levels. BMP4 decreased nephrin expression but increased cleaved caspase-3 levels. p38 suppression inhibited caspase-3 activation. Apoptosis was confirmed in STZ-diabetic glomeruli and Bmp4-overexpressing mice. Bmp4 +/− mice with diabetes displayed reduced apoptosis. Based on these data, the BMP4 signaling pathway plays important roles in the development of both podocyte injury and mesangial matrix expansion in diabetic nephropathy. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Podocyte |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cytokine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
diabetic nephropathy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BMP4 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CKD |
| 書誌情報 |
en : Scientific Reports
巻 8,
p. 13011,
発行日 2018-08-29
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20452322 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yui Fujitaの学位論文として提出され, 学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻） |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© The Author(s) 2018 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
|
|
識別子 |
349274 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
| 報告番号 |
|
|
学位授与番号 |
甲第3240号 |
| 学位記番号 |
|
|
言語 |
ja |
|
値 |
甲医第1389号 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2018-10-25 |
| 学位名 |
|
|
言語 |
ja |
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
言語 |
ja |
|
|
学位授与機関名 |
徳島大学 |
k3240_abstract_review.pdf (265 KB)
.png)
