| Item type |
文献 / Documents(1) |
| 公開日 |
2019-01-11 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1007/s10753-018-0764-0 |
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|
関連名称 |
10.1007/s10753-018-0764-0 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Distinct Regulation of CXCL10 Production by Cytokines in Human Salivary Gland Ductal and Acinar Cells |
| タイトル別表記 |
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|
その他のタイトル |
Distinct Regulation of CXCL10 Production in Salivary Gland Cells |
| 著者 |
青田, 桂子
可児, 耕一
山ノ井, 朋子
ナカシロ, コウイチ
石丸, 直澄
東, 雅之
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| 抄録 |
|
|
内容記述 |
CXCL10, a CXC chemokine induced by interferon-gamma [IFN-γ], has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions. Although CXCL10 is known to be overexpressed in the salivary glands of individuals with primary Sjögren's syndrome (pSS), it is unclear which cells produce CXCL10 under what types of stimulations. Here we investigated the precise molecular mechanisms by which CXCL10 was produced in human salivary gland ductal (NS-SV-DC) and acinar (NS-SV-AC) cell lines. Our results demonstrated that NS-SV-DC cells produced higher levels of CXCL10 compared to NS-SV-AC cells. In addition, our findings demonstrated that the regulator of the enhancement of CXCL10 was different between NS-SV-DC and NS-SV-AC cells; i.e., interferon-gamma (IFN-γ) had more potential than interferon-alpha (IFN-α), tumor necrosis factor (TNF)-α, and interleukin (IL)1-β in the induction of CXCL10 production in NS-SV-DC cells, whereas TNF-α had potential to induce CXCL10 production in NS-SV-AC cells. A Western blot analysis demonstrated that IFN-γ enhanced the production of CXCL10 via both the JAK/STAT1 pathway and the NF-κB pathway in NS-SV-DC cells, whereas TNF-α enhanced the production of CXCL10 via the NF-κB pathway in NS-SV-AC cells. The results of study suggest that the CXCL10 overexpression in the salivary glands is caused mainly by IFN-γ-stimulated salivary gland ductal cells. The enhanced production of CXCL10 by IFN-γ from ductal cells may result in the inflammation of pSS lesions. |
| キーワード |
|
|
主題 |
CXCL10 |
| キーワード |
|
|
主題 |
IFN-γ |
| キーワード |
|
|
主題 |
TNF-α |
| キーワード |
|
|
主題 |
primary Sjögren’s syndrome |
| キーワード |
|
|
主題 |
salivary gland ductal cells |
| キーワード |
|
|
主題 |
salivary gland acinar cells |
| 書誌情報 |
en : Inflammation
巻 41,
号 4,
p. 1172-1181,
発行日 2018-03-17
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03603997 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15732576 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00673765 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12117940 |
| 出版者 |
|
|
出版者 |
Springer US |
| 備考 |
|
|
値 |
The final publication is available at link.springer.com |
| EID |
|
|
識別子 |
341824 |
| 言語 |
|
|
言語 |
eng |
Inflammation_41_4_1172.pdf (917 KB)
