| Item type |
文献 / Documents(1) |
| 公開日 |
2019-01-29 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1159/000438617 |
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関連名称 |
10.1159/000438617 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
IL-4 Modulates CCL11 and CCL20 Productions from IL-1β-Stimulated Human Periodontal Ligament Cells |
| タイトル別表記 |
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その他のタイトル |
IL-4 Modulates Chemokine Productions in Fibroblast |
| 著者 |
細川, 義隆
細川, 育子
シンドウ, サトル
尾崎, 和美
松尾, 敬志
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| 抄録 |
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内容記述 |
Background/Aims: IL-4 is a multifunctional cytokine that is related with the pathological conditions of periodontal disease. However, it is uncertain whether IL-4 could control T cells migration in periodontal lesions. The aim of this study was to examine the effects of IL-4 on CCL11, which is a Th2-type chemokine, and CCL20, which is related with Th17 cells migration, productions from human periodontal ligament cells (HPDLCs). Methods: CCL20 and CCL11 productions from HPDLCs were monitored by ELISA. Western blot analysis was performed to detect phosphorylations of signal transduction molecules in HPDLCs. Results: IL-1β could induce both CCL11 and CCL20 productions in HPDLCs. IL-4 enhanced CCL11 productions from IL-1β-stimulated HPDLCs, though IL-4 inhibited CCL20 production. Western blot analysis showed that protein kinase B (Akt) and signal transducer and activator of transcription (STAT)6 pathways were highly activated in IL-4/IL-1β-stimulated HPDLCs. Akt and STAT6 inhibitors decreased CCL11 production, but enhanced CCL20 production in HPDLCs stimulated with IL-4 and IL-1β. Conclusions: These results mean that IL-4 enhanced Th2 cells migration in periodontal lesion to induce CCL11 production from HPDLCs. On the other hand, IL-4 inhibits Th17 cells accumulation in periodontally diseased tissues to inhibit CCL20 production. Therefore, IL-4 is positively related with the pathogenesis of periodontal disease to control chemokine productions in periodontal lesions. |
| キーワード |
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主題 |
IL-4 |
| キーワード |
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主題 |
CCL11 |
| キーワード |
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|
主題 |
CCL20 |
| キーワード |
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|
主題 |
STAT6 |
| キーワード |
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|
主題 |
Periodontal ligament cells |
| 書誌情報 |
en : Cellular Physiology and Biochemistry
巻 38,
号 1,
p. 153-159,
発行日 2016-01-15
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10158987 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14219778 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12780988 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10801409 |
| 出版者 |
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出版者 |
S. Karger AG, Basel |
| 権利情報 |
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|
権利情報 |
©2016 Author(s). This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. |
| EID |
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|
識別子 |
314798 |
| 言語 |
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|
言語 |
eng |
cell_physiol_biochem_38_1_153.pdf (711 KB)
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