| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2019-01-29 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1155/2017/2850947 |
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関連名称 |
10.1155/2017/2850947 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Antibiofilm and Anti-Inflammatory Activities of Houttuynia cordata Decoction for Oral Care |
| 著者 |
セキタ, ヤスコ
村上, 圭史
湯本, 浩通
平尾, 功治
天羽, 崇
藤原, 奈津美
弘田, 克彦
藤猪, 英樹
松尾, 敬志
三宅, 洋一郎
柏田, 良樹
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| 抄録 |
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内容記述 |
Dental biofilms that form in the oral cavity play a critical role in the pathogenesis of several infectious oral diseases, including dental caries, periodontal disease, and oral candidiasis. Houttuynia cordata (HC, Saururaceae) is a widely used traditional medicine, for both internal and external application. A decoction of dried HC leaves (dHC) has long been consumed as a health-promoting herbal tea in Japan. We have recently reported that a water solution of HC poultice ethanol extract (wHCP) exerts antimicrobial and antibiofilm effects against several important oral pathogens. It also exhibits anti-inflammatory effects on human keratinocytes. In our current study, we examined the effects of dHC on infectious oral pathogens and inflammation. Our results demonstrated that dHC exerts moderate antimicrobial effects against methicillin-resistant Staphylococcus aureus (MRSA) and other oral microorganisms. dHC also exhibited antibiofilm effects against MRSA, Fusobacterium nucleatum (involved in dental plaque formation), and Candida albicans and inhibitory effects on interleukin-8, CCL20, IP-10, and GRO𝛼 productions by human oral keratinocytes stimulated by Porphyromonas gingivalis lipopolysaccharide (a cause of periodontal disease), without cytotoxic effects. This suggests that dHC exhibits multiple activities in microorganisms and host cells. dHC can be easily prepared and may be effective in preventing infectious oral diseases. |
| 書誌情報 |
en : Evidence-Based Complementary and Alternative Medicine
巻 2017,
p. 2850947,
発行日 2017-10-16
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1741427X |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
17414288 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11968793 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12050781 |
| 出版者 |
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出版者 |
Hindawi |
| 権利情報 |
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|
権利情報 |
Copyright © 2017 Yasuko Sekita et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| EID |
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|
識別子 |
335408 |
| 言語 |
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|
言語 |
eng |
ecam_2017_2850947.pdf (1.96 MB)
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