| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2019-01-29 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.jdsr.2018.03.001 |
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関連名称 |
10.1016/j.jdsr.2018.03.001 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
The roles of odontoblasts in dental pulp innate immunity |
| タイトル別表記 |
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その他のタイトル |
Odontoblasts in dental pulp innate immunity |
| 著者 |
湯本, 浩通
平尾, 功治
WEKO
484
e-Rad_Researcher
00581399
| ja |
平尾, 功治
平尾, 功治
ISNI
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| ja-Kana |
ヒラオ, コウジ
ヒラオ, コウジ
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| en |
Hirao, Kouji
Hirao, Kouji
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Search repository
細川, 由樹
クラモト, ヒトミ
武川, 大輔
中西, 正
松尾, 敬志
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| 抄録 |
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内容記述 |
Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbial pathogens, especially pathogen-associated molecular patterns (PAMPs) shared by microorganisms, are mediated by pattern recognition receptors (PRRs), such as Toll-like receptor and the nucleotide-binding oligomerization domain (NOD). The innate immune responses in odontoblasts initiated by sensing oral pathogens provide host protective events, such as inflammatory reactions, to produce a variety of pro-inflammatory mediators, including chemokines and cytokines. These attract various inflammatory cells and cause antibacterial reactions, such as the production of defensins, to kill microorganisms in the proximal region of the odontoblast layer. This review focuses on innate immunity, especially cellular and molecular mechanisms regarding the sensing of PAMPs from oral pathogens by PRRs, in odontoblasts and provides information for future studies for the development of novel therapeutic strategies, including diagnosis and treatment, to prevent exceeding dental pulp inflammation and preserve the dental pulp tissues. |
| キーワード |
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主題 |
Odontoblast |
| キーワード |
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主題 |
Pattern recognition |
| キーワード |
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主題 |
receptor |
| キーワード |
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主題 |
Pathogen-associated molecular pattern |
| キーワード |
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主題 |
Inflammation |
| キーワード |
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主題 |
Pro-inflammatory mediator |
| キーワード |
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主題 |
Damage-associated molecular pattern |
| 書誌情報 |
en : Japanese Dental Science Review
巻 54,
号 3,
p. 105-117,
発行日 2018-03-27
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
18827616 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12334461 |
| 出版者 |
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出版者 |
Japanese Association for Dental Science |
| 出版者 |
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出版者 |
Elsevier |
| 権利情報 |
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権利情報 |
© 2018 The Authors. Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
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識別子 |
343607 |
| 言語 |
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言語 |
eng |
jdsr_54_3_105.pdf (1.42 MB)
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