| Item type |
文献 / Documents(1) |
| 公開日 |
2019-01-29 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/rmb2.12026 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1002/rmb2.12026 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Clinical outcome of various metformin treatments for women with polycystic ovary syndrome |
|
言語 |
en |
| 著者 |
松崎, 利也
Tungalagsuvd, Altankhuu
岩佐, 武
Munkhzaya, Munkhsaikhan
矢野, 清人
Mayila, Yiliyasi
トクイ, タカコ
ヤナギハラ, リエ
松井, 寿美佳
加藤, 剛志
桑原, 章
苛原, 稔
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aim: Polycystic ovary syndrome (PCOS) is an ovulatory disorder and insulin resistance and diabetes are involved in its pathophysiology. Metformin, an anti‐diabetic agent, has been reported to be useful to induce ovulation.
Methods: Metformin treatment was classified into four types: (1) clomiphene–metformin combination treatment for clomiphene‐resistant patients; (2) clomiphene–metformin combination for clomiphene‐sensitive patients; (3) clomiphene–metformin combination for naïve patients; and (4) metformin monotherapy. The patients underwent physical, endocrinological, and clinical examinations for their ovulation rates, pregnancy rates, and follicular development.
Results: The ovulation rates, pregnancy rates, and single follicular development were not significantly different among the clomiphene–metformin combination treatment groups. In the Body Mass Index (BMI) subanalysis, the pregnancy rate was higher in the BMI≥30 kg/m2 group than in the other three groups with a BMI of ≤30 kg/m2 in both cycles and cases. The ovulation rates and pregnancy rates were significantly higher in the group with a fasting insulin of ≥15 μU/mL than in the groups with a fasting insulin of <15 μU/mL in both cycles and cases.
Conclusion: Clomiphene–metformin combination treatment appears to be useful, at least for clomiphene‐resistant patients, and a BMI of >30 kg/m2 and a fasting insulin of ≥15 μU/mL appear to be predictors of a good result with this treatment. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
clomiphene |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
metformin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ovulation induction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
polycystic ovary syndrome |
| 書誌情報 |
en : Reproductive Medicine and Biology
巻 16,
号 2,
p. 179-187,
発行日 2017-04-04
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14470578 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11706516 |
| 出版者 |
|
|
出版者 |
Japan Society for Reproductive Medicine |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
John Wiley & Sons Australia, Ltd |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
339189 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
rmb_16_2_179.pdf (331 KB)
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