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Cellular prion protein-mediated protection against influenza A virus infection
https://tokushima-u.repo.nii.ac.jp/records/2006205
https://tokushima-u.repo.nii.ac.jp/records/2006205e2bfa0e1-a086-4553-a806-2edad3503a42
| 名前 / ファイル | ライセンス | アクション |
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fvl_14_1_31.pdf (298 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2019-03-14 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.2217/fvl-2018-0146 | |||||||||||||||||
| 関連名称 | 10.2217/fvl-2018-0146 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Cellular prion protein-mediated protection against influenza A virus infection | |||||||||||||||||
| タイトル別表記 | ||||||||||||||||||
| その他のタイトル | Prion protein in influenza A virus infection. | |||||||||||||||||
| 著者 |
千田, 淳司
× 千田, 淳司
WEKO
307
× 坂口, 末廣
WEKO
220
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| 抄録 | ||||||||||||||||||
| 内容記述 | The cellular prion protein, termed PrPC, is a glycoprotein abundantly expressed in brains and to a lesser extent in non-neuronal tissues including lungs. It was reported that PrPC is expressed by lung epithelial cells in mice, and that it may play a protective role against lethal infection with influenza A viruses (IAVs). This may occur by regulating Cu content and superoxide dismutase activity, eventually reducing oxidative stress in infected lungs. Anti-oxidative therapeutics have been demonstrated to protect mice from lethal infection with IAVs. Therefore, PrPC might be a new target molecule for development of IAV therapeutics. Here, we introduce the anti-viral mechanism of PrPC against IAV infection and discuss perspectives of PrPC-targeting therapeutics against IAV infection. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | influenza A virus | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | prion protein | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | reactive oxygen species | |||||||||||||||||
| 書誌情報 |
en : Future Virology 巻 14, 号 1, p. 31-37, 発行日 2018-12-18 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 17460794 | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 17460808 | |||||||||||||||||
| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA12157333 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Future Medicine Ltd | |||||||||||||||||
| 備考 | ||||||||||||||||||
| 値 | This is the Authors' final version of the following article: Cellular prion protein-mediated protection against influenza A virus infection, Junji Chida and Suehiro Sakaguchi, Future Virology 2019 14:1, 31-37, which has been published in final form at https://doi.org/10.2217/fvl-2018-0146. For full bibliographic citation, please refer to the version available at www.futuremedicine.com. | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 356504 | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
