| Item type |
文献 / Documents(1) |
| 公開日 |
2019-04-16 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3389/fneur.2018.01099 |
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関連名称 |
10.3389/fneur.2018.01099 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies : A Cohort Study |
| タイトル別表記 |
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その他のタイトル |
TTS in ALS and Synucleinopathies |
| 著者 |
和泉, 唯信
宮本, 亮介
藤田, 浩司
山本, 雄貴
山田, 博胤
マツバラ, トモヤス
ウナイ, ユウキ
ツカモト, アイ
タカマツ, ナオコ
野寺, 裕之
ハヤシ, シンヤ
オダ, マサヤ
モリ, アツコ
ニシダ, ヨシヒコ
ワタナベ, シュンスケ
小川, 博久
上原, 久典
ムラヤマ, シゲオ
佐田, 政隆
梶, 龍兒
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| 抄録 |
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内容記述 |
Takotsubo syndrome (TTS) is an acute cardiac syndrome characterized by regional left ventricular dysfunction with a peculiar circumferential pattern, which typically results in apical ballooning. Evidence indicates a pivotal role of catecholamines in TTS, and researchers have discussed multiple hypotheses on the etiology, including multivessel coronary spasm, myocardial stunning, excessive transient ventricular afterload, and cardiac sympathetic overactivity with local noradrenaline spillover. Although central nervous system disorders, such as stroke and epilepsy, are known to trigger TTS, the incidence and clinical features of TTS in neurodegenerative disorders are poorly understood. Here, we retrospectively examined TTS cases in a single-center cohort composed of 250 patients with amyotrophic lateral sclerosis (ALS) and 870 patients with synucleinopathies [582 patients with Parkinson’s disease (PD), 125 patients with dementia with Lewy bodies (DLB), and 163 patients with multiple system atrophy (MSA)] and identified 4 (1.6%, including 2 women) cases with ALS and no cases with synucleinopathies. Two ALS patients underwent autopsy and the pathological findings were compatible with the chronological changes identified in catecholamine-induced cardiomyopathy. A literature review identified 16 TTS cases with ALS, 1 case each with PD and DLB, and no cases with MSA. When current and previous TTS cases with ALS were concatenated: 55% (11/20) were female; 35% (7/20) had a bulbar-onset and 45% (9/20) had a limb-onset; the mean age of TTS onset was 63.3 ± 9.0 years and the mean interval time from ALS onset to TTS development was 4.9 ± 3.0 years; no (0/16) patients developed TTS within 12 months after ALS onset; 50% (10/20) underwent artificial ventilations; the mortality was 17% (3/18); and most cases had precipitating factors, and TTS development was associated with gastrostomy, tracheostomy, or infections in 45% (9/20) of the patients. This study demonstrated that ALS is a considerable predisposing factor of TTS and that synucleinopathies rarely cause TTS. The distinct TTS incidence between ALS and synucleinopathies may be due to cardiac sympathetic overactivity in ALS and may also be affected by cardiac sympathetic denervation in synucleinopathies. Moreover, the etiology of TTS in ALS may be reasonably explained by the two-hit theory. |
| キーワード |
|
|
主題 |
takotsubo syndrome |
| キーワード |
|
|
主題 |
amyotrophic lateral sclerosis |
| キーワード |
|
|
主題 |
synucleinopathy |
| キーワード |
|
|
主題 |
Parkinson’s disease |
| キーワード |
|
|
主題 |
dementia with Lewy bodies |
| キーワード |
|
|
主題 |
multiple system atrophy |
| キーワード |
|
|
主題 |
sympathetic nerve |
| キーワード |
|
|
主題 |
noradrenaline |
| 書誌情報 |
en : Frontiers in Neurology
巻 9,
p. 1099,
発行日 2018-12-13
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16642295 |
| 出版者 |
|
|
出版者 |
Frontiers |
| 権利情報 |
|
|
権利情報 |
Copyright © 2018 Izumi, Miyamoto, Fujita, Yamamoto, Yamada, Matsubara, Unai, Tsukamoto, Takamatsu, Nodera, Hayashi, Oda, Mori, Nishida, Watanabe, Ogawa, Uehara, Murayama, Sata and Kaji.This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
350356 |
| 言語 |
|
|
言語 |
eng |
fneur_9_1099.pdf (2.29 MB)
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