| Item type |
文献 / Documents(1) |
| 公開日 |
2019-05-14 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://journals.lww.com/jhypertension/Fulltext/2019/01000/Development_of_a_novel_aortic_dissection_mouse.15.aspx |
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|
関連名称 |
10.1097/HJH.0000000000001898 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Development of a novel aortic dissection mouse model and evaluation of drug efficacy using in-vivo assays and database analyses |
| タイトル別表記 |
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その他のタイトル |
Drug efficacy against aortic dissection |
| 著者 |
(井澤)石澤, 有紀
今西, 正樹
座間味, 義人
トヤ, ヒロキ
ナガオ, トモコ
モリシタ, マリン
常山, 幸一
堀ノ内, 裕也
木平, 孝高
武智, 研志
池田, 康将
土屋, 浩一郎
吉栖, 正典
玉置, 俊晃
石澤, 啓介
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| 抄録 |
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内容記述 |
Objective: Aortic dissection is a life-threatening disease. At present, the only therapeutic strategies available are surgery and antihypertensive drugs. Moreover, the molecular mechanisms underlying the onset of aortic dissection are still unclear. We established a novel aortic dissection model in mice using pharmacologically induced endothelial dysfunction. We then used the Japanese Adverse Drug Event Report database to investigate the role of pitavastatin in preventing the onset of aortic dissection.
Methods and results: To induce endothelial dysfunction, Nω-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, was administered to C57BL/6 mice. Three weeks later, angiotensin II (Ang II) and β-aminopropionitrile (BAPN), a lysyl oxidase inhibitor, were administered with osmotic mini-pumps. False lumen formation was used as the pathological determinant of aortic dissection. The incidences of aortic dissection and death from aneurysmal rupture were significantly higher in the Nω-nitro-L-arginine methyl ester, Ang II, and BAPN (LAB) group than they were in the Ang II and BAPN (AB) group.
Pitavastatin was administered orally to LAB mice. It significantly lowered the incidences of dissection and rupture. It also decreased inflammation and medial degradation, both of which were exacerbated in the LAB group. The Japanese Adverse Drug Event Report database
analysis indicated that there were 113 cases of aortic dissection out of 95 090 patients (0.12%) not receiving statins but only six cases out of 16 668 patients receiving statins (0.04%) (odds ratio: 0.30; P=0.0043).
Conclusion: Our results suggest that endothelial dysfunction is associated with the onset of aortic dissection and pitavastatin can help prevent this condition. |
| キーワード |
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|
主題 |
angiotensin II |
| キーワード |
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|
主題 |
aortic dissection |
| キーワード |
|
|
主題 |
endothelial dysfunction |
| キーワード |
|
|
主題 |
lysyl oxidase inhibitor |
| キーワード |
|
|
主題 |
nitric oxide synthase inhibitor |
| キーワード |
|
|
主題 |
pitavastatin |
| キーワード |
|
|
主題 |
the Japanese Adverse Drug Event Report Database |
| 書誌情報 |
en : Journal of Hypertension
巻 37,
号 1,
p. 73-83,
発行日 2019-01-01
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
02636352 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14735598 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10644107 |
| 出版者 |
|
|
出版者 |
Wolters Kluwer Health |
| 権利情報 |
|
|
権利情報 |
© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
| EID |
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|
識別子 |
347382 |
| 言語 |
|
|
言語 |
eng |
johy_37_1_73.pdf (1.13 MB)
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