| Item type |
文献 / Documents(1) |
| 公開日 |
2019-05-16 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.3892/mmr.2019.10141 |
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|
関連名称 |
10.3892/mmr.2019.10141 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
Combination of ions promotes cell migration via extracellular signal-regulated kinase 1/2 signaling pathway in human gingival fibroblasts |
| タイトル別表記 |
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その他のタイトル |
COMBINATION OF IONS PROMOTES GINGIVAL FIBROBLAST MIGRATION |
| 著者 |
(山口)上田, 公子
赤澤, 友基
河原林, 啓太
杉本, 明日菜
中川, 弘
宮嵜, 彩
クロゴウシ, リカ
イワタ, ココロ
北村, 尚正
ヤマダ, アヤ
長谷川, 智一
フクモト, サトシ
岩本, 勉
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| 抄録 |
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内容記述 |
Wound healing is a dynamic process that involves highly coordinated cellular events, including proliferation and migration. Oral gingival fibroblasts serve a central role in maintaining oral mucosa homeostasis, and their functions include the coordination of physiological tissue repair. Recently, surface pre‑reacted glass‑ionomer (S‑PRG) fillers have been widely applied in the field of dental materials for the prevention of dental caries, due to an excellent ability to release fluoride (F). In addition to F, S‑PRG fillers are known to release several types of ions, including aluminum (Al), boron (B), sodium (Na), silicon (Si) and strontium (Sr). However, the influence of these ions on gingival fibroblasts remains unknown. The aim of the present study was to examine the effect of various concentrations of an S‑PRG filler eluate on the growth and migration of gingival fibroblasts. The human gingival fibroblast cell line HGF‑1 was treated with various dilutions of an eluent solution of S‑PRG, which contained 32.0 ppm Al, 1,488.6 ppm B, 505.0 ppm Na, 12.9 ppm Si, 156.5 ppm Sr and 136.5 ppm F. Treatment with eluate at a dilution of 1:10,000 was observed to significantly promote the migration of HGF‑1 cells. In addition, the current study evaluated the mechanism underlying the mediated cell migration by the S‑PRG solution and revealed that it activated the phosphorylation of extracellular signal‑regulated kinase 1/2 (ERK1/2), but not of p38. Furthermore, treatment with a MEK inhibitor blocked the cell migration induced by the solution. Taken together, these results suggest that S‑PRG fillers can stimulate HGF‑1 cell migration via the ERK1/2 signaling pathway, indicating that a dental material containing this type of filler is useful for oral mucosa homeostasis and wound healing. |
| キーワード |
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|
主題 |
gingival fibroblasts |
| キーワード |
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|
主題 |
cell migration |
| キーワード |
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|
主題 |
extracellular signal‑regulated kinase signaling |
| キーワード |
|
|
主題 |
multiple‑ion solution |
| キーワード |
|
|
主題 |
surface pre‑reacted glass‑ionomer filler |
| 書誌情報 |
en : Molecular Medicine Reports
巻 19,
号 6,
p. 5039-5045,
発行日 2019-04-08
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17912997 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17913004 |
| 出版者 |
|
|
出版者 |
Spandidos Publications |
| EID |
|
|
識別子 |
349214 |
| 言語 |
|
|
言語 |
eng |
mmr_19_6_5039.pdf (641 KB)
