| Item type |
文献 / Documents(1) |
| 公開日 |
2019-06-05 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.2147/NDT.S163132 |
|
|
関連名称 |
10.2147/NDT.S163132 |
| 出版タイプ |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
|
|
タイトル |
Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia : an ICA resting-state fMRI study |
| タイトル別表記 |
|
|
その他のタイトル |
統合失調症におけるSalience Network機能障害、抑うつ気分、および主観的QOLの因果関係を評価する構造方程式モデリングアプローチ : 独立成分分析による安静時ｆMRI研究 |
| 著者 |
大田, 将史
中瀧, 理仁
武田, 知也
沼田, 周助
富永, 武男
亀岡, 尚美
久保, 弘子
木下, 誠
マツウラ, カナエ
オオトモ, マキ
タケイチ, ナオヤ
原田, 雅史
大森, 哲郎
|
| 抄録 |
|
|
内容記述 |
Purpose: Quality of life (QOL) is an important clinical outcome for patients with schizophrenia, and recent studies have focused on subjective QOL. We evaluated the causal relationship between psychosocial aspect of subjective QOL, symptoms, cognitive functions, and salience network (SN) dysfunction in schizophrenia using structural equation modeling (SEM).
Patients and methods: We performed a cross-sectional study of 21 patients with symptomatically stabilized schizophrenia and 21 age-, sex-, and education level-matched healthy controls who underwent resting-state functional magnetic resonance imaging. We evaluated SN dysfunction in schizophrenia using independent component analysis (ICA). We rated participant psychopathology using the Positive and Negative Syndrome Scale (PANSS), the Brief Assessment of Cognition in Schizophrenia (BACS), and the Calgary Depression Scale for Schizophrenia (CDSS). We rated psychosocial aspect of subjective QOL using the Schizophrenia Quality of Life Scale (SQLS) psychosocial subscale. We applied SEM to examine the relationships between SN dysfunction, PANSS positive and negative scores, CDSS total scores, BACS composite scores, and SQLS psychosocial subscale scores.
Results: In second-level analysis after group ICA, patient group had significant lower right pallidum functional connectivity (FC) within the SN than the controls did (Montreal Neurological Institute [MNI] [x y z] = [22 -2 -6]) (p = 0.027, family-wise error [FWE] corrected). In SEM, we obtained a good fit for an SEM model in which SN dysfunction causes depressed mood, which in turn determines psychosocial aspect of subjective QOL (chi-squared p = 0.9, root mean square error of approximation (RMSEA) < 0.001, comparative fit index [CFI] = 1.00, and standardized root mean square residual [SRMR]= 0.020).
Conclusion: We found a continuous process by which SN dysfunction causes depressed moods that determine psychosocial aspect of subjective QOL in schizophrenia. This is the first report that offers a unified explanation of functional neuroimaging, symptoms, and outcomes. Future studies combining neuroimaging techniques and clinical assessments would elucidate schizophrenia’s pathogenesis. |
| キーワード |
|
|
主題 |
depressed mood |
| キーワード |
|
|
主題 |
salience network |
| キーワード |
|
|
主題 |
schizophrenia |
| キーワード |
|
|
主題 |
structural equation modeling |
| キーワード |
|
|
主題 |
subjective quality of life |
| キーワード |
|
|
主題 |
resting-state fMRI |
| 書誌情報 |
en : Neuropsychiatric Disease and Treatment
巻 14,
p. 1585-1597,
発行日 2018-06-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
11782021 |
| 出版者 |
|
|
出版者 |
Dovepress |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Masashi Ohtaの学位論文として提出され, 学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻） |
| 権利情報 |
|
|
権利情報 |
© 2018 Ohta et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
| EID |
|
|
識別子 |
350688 |
| 言語 |
|
|
言語 |
eng |
| 報告番号 |
|
|
学位授与番号 |
甲第3255号 |
| 学位記番号 |
|
|
値 |
甲医第1404号 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2019-03-22 |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関名 |
徳島大学 |
k3255_abstract_review.pdf (258 KB)
.png)
