| Item type |
文献 / Documents(1) |
| 公開日 |
2019-06-07 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2485/jhtb.27.213 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2485/jhtb.27.213 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effect of Short-term Tumour Necrosis Factor-alpha (TNF-α) -stimulation on the Growth and Differentiation of MC3T3-E1 Osteoblast-like Cells |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Effect of Short-term TNF-α-stimulation of MC3T3-E1 |
|
言語 |
en |
| 著者 |
井上, 美穂
ナリタニ, ミオ
Raju, Resmi
(上枝)宮城, 麻友
オオシマ, マサミツ
イノウエ, マサヒサ
松香, 芳三
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Tumor necrosis factor-alpha (TNF-α) is an inflammatory cytokine known to cause bone resorption, swelling and edema during tissue organization. Conversely, TNF-α has also been shown to participate in tissue regeneration during the wound healing process. We have previously investigated the effects of TNF-α on human dental pulp cell differentiation. Dental pulp cells are composed of different cell types including primary odontoblasts and fibroblasts. We determined that the ratio of stem cells within the pulp cell population was increased following short-term stimulation with TNF-α. The aim of this study therefore was to investigate the effect of short-term stimulation with TNF-α on osteoblast-like MC3T3-E1 cell growth and differentiation. MC3T3-E1 cells were cultured in standard growth medium and on reaching sub-confluence were exposed to recombinant TNF-α (10 and 100 ng/ml) for 2 days prior to assessing their cell proliferation and differentiation properties in comparison to non-stimulated MC3T3-E1 cells (control). Although no significant differences in cell proliferation were observed between the TNF-α-stimulated and control groups, cell differentiation was delayed in the TNF-α-stimulated groups. In summary, short-term stimulation of cultured MC3T3-E1 cells with TNF-α had only minimal effect on their growth and differentiation. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TNF-α |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Osteoblast-like cell (MC3T3-E1) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cell proliferation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cell differentiation |
| 書誌情報 |
en : Journal of Hard Tissue Biology
巻 27,
号 3,
p. 213-218,
発行日 2018-07-01
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13417649 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1880828X |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11074332 |
| 出版者 |
|
|
出版者 |
The Society for Hard Tissue Regenerative Biology |
|
言語 |
en |
| EID |
|
|
識別子 |
354307 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jhtb_27_3_213.pdf (739 KB)
