WEKO3
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RootNode
アイテム
Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
https://tokushima-u.repo.nii.ac.jp/records/2006571
https://tokushima-u.repo.nii.ac.jp/records/20065718c639821-088e-478a-ae9a-172cbe91cd10
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jdsr_55_1_12.pdf (1.19 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2019-07-29 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.jdsr.2018.09.004 | |||||||||||||||||
| 関連名称 | 10.1016/j.jdsr.2018.09.004 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis | |||||||||||||||||
| 著者 |
フタミ, イスラミ ラフマ
× フタミ, イスラミ ラフマ
× 田中, 栄二
WEKO
323
× 井澤, 俊 |
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| 抄録 | ||||||||||||||||||
| 内容記述 | Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium. Initially, the synovial lining tissue becomes engaged with several kinds of infiltrating cells, including osteoclasts, macrophages, lymphocytes, and plasma cells. Eventually, bone degradation occurs. In order to elucidate the best therapy for RA, a comprehensive study of RA pathogenesis needs to be completed. In this article, we discuss a Fas-deficient condition which develops into RA, with an emphasis on the role of sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling which induces the migration of osteoclast precursor cells. We describe that Fas/S1P1 signaling via NF-kB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-kB subunit as a potential therapy for attenuating osteoclastogenesis. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Temporomandibular joint | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Rheumatoid arthritis | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Osteoclast | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Fas | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | S1P1 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | NF-κB | |||||||||||||||||
| 書誌情報 |
en : Japanese Dental Science Review 巻 55, 号 1, p. 12-19, 発行日 2018-10-26 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 18827616 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA12334461 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Japanese Association for Dental Science | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 権利情報 | © 2018 The Authors. Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 347055 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
