| Item type |
文献 / Documents(1) |
| 公開日 |
2019-07-24 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/S0923-1811(96)00569-5 |
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関連名称 |
10.1016/S0923-1811(96)00569-5 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
p53 gene mutation analysis in porokeratosis and porokeratosis-associated squamous cell carcinoma |
| 著者 |
ニノミヤ, ヨシロウ
ウラノ, ヨシオ
吉本, 勝彦
イワハナ, ヒロユキ
ササキ, シロウ
荒瀬, 誠治
板倉, 光夫
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| 抄録 |
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内容記述 |
In this and previous studies, we have shown p53 overexpression immunohistochemically in 14 of 17 porokeratotic specimens obtained from 14 lesions of nine cases, and in all six specimens of squamous cell carcinoma (SCC) arising on porokeratotic lesions of two cases. We screened mutations in exons 5 to 10 of the p53 gene in all these specimens by polymerase chain reaction-single strand conformation polymorphism analysis. Mutations of the p53 gene were detected in two of the six SCCs but not in any of the 17 porokeratotic specimens. These two mutations were C to T transitions at codons 146 and 175 in exon 5, which were a nonsense mutation at a dipyrimidine site and a missense mutation at a CG site, respectively. To our knowledge, neither of these mutations has been identified in skin cancers before. Our observations indicate that mutations of the p53 gene are not the major molecular etiology for porokeratosis, but are related to its skin carcinogenesis, and that p53 overexpression in porokeratosis is not due to p53 gene mutations. |
| キーワード |
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主題 |
Porokeratosis |
| キーワード |
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主題 |
p53 mutation |
| キーワード |
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|
主題 |
Squamous cell carcinoma |
| キーワード |
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|
主題 |
PCR-SSCP |
| キーワード |
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|
主題 |
Immunohistochemistry |
| 書誌情報 |
en : Journal of Dermatological Science
巻 14,
号 3,
p. 173-178,
発行日 1997-03
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09231811 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1075636X |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11531842 |
| 出版者 |
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|
出版者 |
Elsevier |
| 備考 |
|
|
値 |
本論文は，著者Yoshiro Ninomiyaの学位論文として提出され，学位審査・授与の対象となっている。 |
| EID |
|
|
識別子 |
72037 |
| 言語 |
|
|
言語 |
eng |
jds_14_3_173.pdf (722 KB)
