| Item type |
文献 / Documents(1) |
| 公開日 |
2019-08-06 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.ajpath.2015.07.007 |
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関連名称 |
10.1016/j.ajpath.2015.07.007 |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Impaired Expansion of Regulatory T Cells in a Neonatal Thymectomy-Induced Autoimmune Mouse Model |
| タイトル別表記 |
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その他のタイトル |
Impaired Function of Treg Cells |
| 著者 |
山田, 安希子
牛尾, 綾
新垣, 理恵子
常松, 貴明
工藤, 保誠
林, 良夫
石丸, 直澄
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| 抄録 |
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内容記述 |
Neonatal thymectomy (Tx) in certain mouse strains is known to induce organ-specific autoimmunity due to impaired functions of T cells, including Foxp3+ regulatory T (Treg) cells in the thymus. The precise mechanism underlying the induction of autoimmunity by neonatal Tx remains unclear. One possibility is that depletion of Treg cells breaks down peripheral tolerance. We examined the functions of Treg cells by using a murine Sjögren’s syndrome (SS) model, NFS/sld mice that underwent neonatal Tx. The ratio of Treg cells to effector memory phenotype T cells in Tx mice was significantly lower than that of non-Tx mice. In addition, in vitro induction of peripherally induced Treg cells by transforming growth factor-β (TGF-β) using naïve T cells from SS model mice was severely impaired. The mRNA expression of TGF-β receptor I, II, and Smad3 and -4 in the TGF-β-induced signal transduction pathway of Treg cells in this SS model were lower than those of control mice. In addition, Treg cells in this SS model exhibited an IFN-γ-producing Th1-like phenotype that resembled effector T cells. In conclusion, these results suggest that abnormal expansion and differentiation of Treg cells and inflammatory cytokines produced by Treg cells contribute to the development of autoimmunity. |
| 書誌情報 |
en : The American Journal of Pathology
巻 185,
号 11,
p. 2886-2897,
発行日 2015-09-04
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00029440 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15252191 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00520990 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12024839 |
| 出版者 |
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出版者 |
American Society for Investigative Pathology |
| 出版者 |
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出版者 |
Elsevier |
| 権利情報 |
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|
権利情報 |
© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
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|
識別子 |
315185 |
| 言語 |
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|
言語 |
eng |
ajp_185_11_2886.pdf (6.14 MB)
