| Item type |
文献 / Documents(1) |
| 公開日 |
2019-08-06 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.ajpath.2014.09.006 |
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関連名称 |
10.1016/j.ajpath.2014.09.006 |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
Aromatase Controls Sjögren Syndrome–Like Lesions through Monocyte Chemotactic Protein-1 in Target Organ and Adipose Tissue–Associated Macrophages |
| タイトル別表記 |
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その他のタイトル |
Aromatase Controls Sjögren’s Syndrome-like Lesions through MCP-1 in Target Organ and Adipose Tissue-Associated Macrophages |
| タイトル別表記 |
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|
その他のタイトル |
A Role of Aromatase in Sjögren Syndrome |
| 著者 |
岩浅, 亮彦
新垣, 理恵子
ホンマ, ナオコ
牛尾, 綾
山田, 安希子
近藤, 智之
クロサワ, エミ
クジラオカ, サトコ
常松, 貴明
工藤, 保誠
田中, 栄二
ヨシムラ, ノリコ
ハラダ, ノブヒロ
林, 良夫
石丸, 直澄
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| 抄録 |
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内容記述 |
Several autoimmune diseases are known to develop in postmenopausal women. However, the mechanism by which estrogen deficiency influences autoimmunity is unknown. Aromatase is a converting enzyme from androgens to estrogens. In the present study, we used female aromatase gene knockout (ArKO) mice as a model of estrogen deficiency to investigate the molecular mechanism that underlies the onset and development of autoimmunity. Histological analyses showed that inflammatory lesions in the lacrimal and salivary glands of ArKO mice increased with age. Adoptive transfer of spleen cells or bone marrow cells from ArKO mice into recombination activating gene 2 knockout mice failed to induce the autoimmune lesions. Expression of mRNA encoding proinflammatory cytokines and monocyte chemotactic protein-1 (MCP-1) increased in white adipose tissue (WAT) of ArKO mice and was significantly higher than that in wild-type mice. Moreover, an increased number of inflammatory M-1 macrophage was observed in WAT of ArKO mice. A significantly increased MCP-1 mRNA expression of the salivary gland tissue in ArKO was found together with adiposity. Furthermore, the autoimmune lesions in a murine model of Sjögren’s syndrome (SS) were exacerbated by administration of an aromatase inhibitor. These results suggest that aromatase may play in a key role in the pathogenesis of SS-like lesions by controlling the target organ and adipose tissue-associated macrophage. |
| 書誌情報 |
en : The American Journal of Pathology
巻 185,
号 1,
p. 151-161,
発行日 2014-10-31
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00029440 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15252191 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00520990 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12024839 |
| 出版者 |
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出版者 |
American Society for Investigative Pathology |
| 出版者 |
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出版者 |
Elsevier |
| 権利情報 |
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|
権利情報 |
© 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
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|
識別子 |
290682 |
| 言語 |
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|
言語 |
eng |
ajp_185_1_151.pdf (1.77 MB)
