| Item type |
文献 / Documents(1) |
| 公開日 |
2019-08-07 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1080/20002297.2019.1609839 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1080/20002297.2019.1609839 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
β-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro |
|
言語 |
en |
| 著者 |
田端, 厚之
ヤマダ, タクヤ
オオタニ, ヒロミ
大倉, 一人
友安, 俊文
長宗, 秀明
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Streptococcus anginosus subsp. anginosus (SAA) is one of the opportunistic pathogens in humans that inhabits the oral cavity. The type strain of SAA, NCTC10713T, showed clear β-hemolysis on blood agar plates, and the sole β-hemolytic factor revealed two streptolysin S (SLS) molecules. SLS is well known as the peptide hemolysin produced from the human pathogen S. pyogenes and shows not only hemolytic activity on erythrocytes but also cytotoxic activity in cell culture lines in vitro and in vivo, such as in a mouse infection model. However, no cytotoxic activity of SLS produced from β-hemolytic SAA (β-SAA) has been reported so far. Objective and Design: In this study, the SLS-dependent cytotoxicity of the β-SAA strains including the genetically modified strains was investigated in vitro. Results: The SLS-producing β-SAA showed cytotoxicity in human cell culture lines under the co-cultivation condition and it was found that this cytotoxicity was caused by the SLS secreted into the extracellular milieu. Conclusion: The results from this study suggest that the SLS produced from β-SAA might indicate the cytotoxic potential similar to that of the SLS from S. pyogenes and the SLS-producing β-SAA would be recognized as “a wolf in sheep’s clothing” More attention will be paid to the pathogenicity of β-hemolytic Anginosus group streptococci. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Streptococcus anginosus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Anginosus group streptococci |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
streptolysin S |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SLS |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
β-hemolysis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cytotoxicity |
| 書誌情報 |
en : Journal of Oral Microbiology
巻 11,
号 1,
p. 1609839,
発行日 2019-05-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20002297 |
| 出版者 |
|
|
出版者 |
Taylor & Francis |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
352306 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jom_11_1_1609839.pdf (1.81 MB)
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