| Item type |
文献 / Documents(1) |
| 公開日 |
2019-08-27 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1007/s00018-013-1494-y |
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|
言語 |
ja |
|
|
関連名称 |
10.1007/s00018-013-1494-y |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
The role of periostin in tissue remodeling across health and disease |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Role of periostin |
|
言語 |
en |
| 著者 |
Conway, Simon J.
イズハラ, ケンジ
工藤, 保誠
Litvin, Judith
Markwald, Roger
Ouyang, Gaoliang
Arron, Joseph R.
Holweg, Cecile T. J.
クドウ, アキラ
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| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial–mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Periostin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Extracellular matrix |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Remodeling |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Repair |
| 書誌情報 |
en : Cellular and Molecular Life Sciences
巻 71,
号 7,
p. 1279-1288,
発行日 2013-10-22
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14209071 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1420682X |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11619003 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11112963 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| EID |
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|
識別子 |
300774 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
cmls_71_7_1279.pdf (300 KB)
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