| Item type |
文献 / Documents(1) |
| 公開日 |
2019-09-06 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1074/jbc.M112.446351 |
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関連名称 |
10.1074/jbc.M112.446351 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells |
| タイトル別表記 |
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その他のタイトル |
Selective Effects of Emi1 Depletion in Cancer |
| 著者 |
シミズ, ナツミ
イズミ ナカジマ, ナカコ
常松, 貴明
オガワ, イクコ
カワイ, ヒデヒコ
ヒラヤマ, リョウイチ
フジモリ, アキラ
山田, 安希子
オカヤス, リュウイチ
石丸, 直澄
高田, 隆
工藤, 保誠
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| 抄録 |
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内容記述 |
Background: To improve the effectiveness of chemo- and radiotherapy only in cancer tissue is important for avoiding side effects.
Results: Emi1 depletion enhanced the sensitivity of anticancer reagents and X-ray irradiation in cancer cells.
Conclusion: Emi1 siRNA would be a useful new modality for enhancing the effect of chemo- and radiotherapy in various tumors.
Significance: This work provides new insights regarding synergistic effect of Emi1 knockdown in combination therapies. |
| 書誌情報 |
en : Journal of Biological Chemistry
巻 288,
号 24,
p. 17238-17252,
発行日 2013-05-03
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1083351X |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA1202441X |
| 出版者 |
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出版者 |
The American Society for Biochemistry and Molecular Biology |
| 備考 |
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|
値 |
This research was originally published in the Journal of Biological Chemistry. Natsumi Shimizu, Nakako Izumi Nakajima, Takaaki Tsunematsu, Ikuko Ogawa, Hidehiko Kawai, Ryoichi Hirayama, Akira Fujimori, Akiko Yamada, Ryuichi Okayasu, Naozumi Ishimaru, Takashi Takata and Yasusei Kudo. Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells. J. Biol. Chem. 2013; Vol:288(24) pp.17238-17252. |
| 権利情報 |
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|
権利情報 |
© 2013 by The American Society for Biochemistry and Molecular Biology, Inc. |
| EID |
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|
識別子 |
262412 |
| 言語 |
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|
言語 |
eng |
jbc_288_24_17238.pdf (4.5 MB)
