| Item type |
文献 / Documents(1) |
| 公開日 |
2019-08-27 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0044488 |
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関連名称 |
10.1371/journal.pone.0044488 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer |
| タイトル別表記 |
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その他のタイトル |
Periostin Promotes Tumor Lymphangiogenesis |
| 著者 |
工藤, 保誠
イイヅカ, シンジ
ヨシダ, マキ
Nguyen, Phuong Thao
Siriwardena, Samadarani B. S. M.
常松, 貴明
オオバヤシ, マリコ
アンドウ, トシノリ
ハタケヤマ, ダイジロウ
シバタ, トシユキ
コイズミ, ケイイチ
マエダ, マサヒロ
石丸, 直澄
オガワ, イクコ
高田, 隆
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| 抄録 |
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内容記述 |
Background: Metastasis to regional lymph nodes via lymphatic vessels plays a key role in cancer progression. Tumor lymphangiogenesis is known to promote lymphatic metastasis, and vascular endothelial growth factor C (VEGF-C) is a critical activator of tumor lymphangiogenesis during the process of metastasis. We previously identified periostin as an invasion- and angiogenesis-promoting factor in head and neck squamous cell carcinoma (HNSCC). In this study, we discovered a novel role for periostin in tumor lymphangiogenesis.
Methods and Findings: Periostin overexpression upregulated VEGF-C mRNA expression in HNSCC cells. By using conditioned media from periostin-overexpressing HNSCC cells, we examined tube formation of lymphatic endothelial cells. Conditioned media from periostin-overexpressing cells promoted tube formation. To know the correlation between periostin and VEGF-C, we compared Periostin expression with VEGF-C expression in 54 HNSCC cases by immunohistochemistry. Periostin expression was correlated well with VEGF-C expression in HNSCC cases. Moreover, correlation between periostin and VEGF-C secretion was observed in serum from HNSCC patients. Interestingly, periostin itself promoted tube formation of lymphatic endothelial cells independently of VEGF-C. Periostin-promoted lymphangiogenesis was mediated by Src and Akt activity. Indeed possible correlation between periostin and lymphatic status in periostin-overexpressing xenograft tumors and HNSCC cases was observed.
Conclusions: Our findings suggest that periostin itself as well as periostin-induced upregulation of VEGF-C may promote lymphangiogenesis. We suggest that periostin may be a marker for prediction of malignant behaviors in HNSCC and a potential target for future therapeutic intervention to obstruct tumoral lymphatic invasion and lymphangiogenesis in HNSCC patients. |
| 書誌情報 |
en : PLOS ONE
巻 7,
号 8,
p. e44488,
発行日 2012-08-30
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
19326203 |
| 出版者 |
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出版者 |
PLOS |
| 権利情報 |
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権利情報 |
© 2012 Kudo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
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識別子 |
257373 |
| 言語 |
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言語 |
eng |
pone_7_8_e44488.pdf (5.02 MB)
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