| Item type |
文献 / Documents(1) |
| 公開日 |
2019-08-27 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/j.1600-0714.2010.00966.x |
|
|
言語 |
ja |
|
|
関連名称 |
10.1111/j.1600-0714.2010.00966.x |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
N-cadherin expression in SpCC |
|
言語 |
en |
| 著者 |
Nguyen, Phuong Thao
工藤, 保誠
ヨシダ, マキ
イイヅカ, シンジ
オガワ, イクコ
高田, 隆
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Spindle cell carcinoma (SpCC) is a biphasic tumor composed of conventional squamous cell carcinoma and a malignant spindle cell component. SpCC expresses both epithelial and mesenchymal markers by immunohistochemical analysis. There is mounting evidence for sarcomatoid transformation from the epithelial component, supporting the theory that SpCC is a monoclonal neoplasm originating from a stem cell giving rise to both components. The loss of E-cadherin and the gain of N-cadherin expression are known as the “cadherin switching”. Cadherin switching is a major hallmark of epithelial-mesenchymal transition (EMT). EMT is a crucial process in cancer progression providing cancer cells with the ability to escape from the primary focus, to invade stromal tissues and to migrate to distant regions. Although E-cadherin down-regulation is well known in various cancers, there are a few studies on N-cadherin expression in cancer. Here, therefore, we investigated N-cadherin expression in the progression of head and neck SpCC. First we examined cadherin swithching in our established SpCC cell lines, SpCC-1 and SpCC-2. SpCC-1 and SpCC-2 cells were spindle in shape and showed cadherin switching. Moreover, we examined N-cadherin expression in 15 SpCC cases by immunohistochemistry. Although N-cadherin expression was not observed in non-neoplastic squamous epithelium, high expression of N-cadherin was observed in 10 of 15 SpCC cases. Interestingly, 6 of 7 SpCC cases with metastasis showed high expression of N-cadherin. In conclusion, our findings suggest that N-cadherin may play an important role in metastasis of SpCC in addition to the pathogenesis of SpCC of the head and neck. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
epithelial–mesenchymal transition |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
N-cadherin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
spindle cell squamous cell carcinoma |
| 書誌情報 |
en : Journal of Oral Pathology & Medicine
巻 40,
号 1,
p. 77-82,
発行日 2010-11-10
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09042512 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16000714 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10715555 |
| 出版者 |
|
|
出版者 |
John Wiley & Sons A/S |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is the peer reviewed version of the following article: Nguyen, P. T., Kudo, Y. , Yoshida, M. , Iizuka, S. , Ogawa, I. and Takata, T. (2011), N‐cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. Journal of Oral Pathology & Medicine, 40: 77-82, which has been published in final form at https://doi.org/10.1111/j.1600-0714.2010.00966.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| EID |
|
|
識別子 |
247612 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jopm_40_1_77.pdf (560 KB)
