| Item type |
文献 / Documents(1) |
| 公開日 |
2019-08-27 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pone.0005892 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1371/journal.pone.0005892 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
RUNX3 Has an Oncogenic Role in Head and Neck Cancer |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
RUNX3 Has an Oncogenic Role |
|
言語 |
en |
| 著者 |
常松, 貴明
工藤, 保誠
イイズカ, シンジ
オガワ, イクコ
フジタ, ツヨシ
クリハラ, ヒデミ
アビコ, ヨシミツ
高田, 隆
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of cancer and appears to be an important component of the transforming growth factor-beta (TGF-ß)-induced tumor suppression pathway. Surprisingly, we found that RUNX3 expression level in head and neck squamous cell carcinoma (HNSCC) tissues, which is one of the most common types of human cancer, was higher than that in normal tissues by a previously published microarray dataset in our preliminary study. Therefore, here we examined the oncogenic role of RUNX3 in HNSCC.
Principal Findings: Frequent RUNX3 expression and its correlation with malignant behavior were observed in HNSCC. Ectopic RUNX3 overexpression promoted cell growth and inhibited serum starvation-induced apoptosis and chemotherapeutic drug induced apoptosis in HNSCC cells. These findings were confirmed by RUNX3 knockdown. Moreover, RUNX3 overexpression enhanced tumorsphere formation. RUNX3 expression level was well correlated with the methylation status in HNSCC cells. Moreover, RUNX3 expression was low due to the methylation of its promoter in normal oral epithelial cells.
Conclusions/Significance: Our findings suggest that i) RUNX3 has an oncogenic role in HNSCC, ii) RUNX3 expression observed in HNSCC may be caused in part by demethylation during cancer development, and iii) RUNX3 expression can be a useful marker for predicting malignant behavior and the effect of chemotherapeutic drugs in HNSCC. |
|
言語 |
en |
| 書誌情報 |
en : PLOS ONE
巻 4,
号 6,
p. e5892,
発行日 2009-06-12
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2009 Tsunematsu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
|
|
識別子 |
247615 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_4_6_e5892.pdf (926 KB)
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