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Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor‑κB activity in human oral cancer cells
https://tokushima-u.repo.nii.ac.jp/records/2006640
https://tokushima-u.repo.nii.ac.jp/records/2006640aa2e5e47-e3bb-4aca-b1ae-6a87a522c242
| 名前 / ファイル | ライセンス | アクション |
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ijo_42_3_935.pdf (1.32 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||
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| 公開日 | 2019-08-30 | |||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3892/ijo.2013.1786 | |||||||||||||||||||||||||||||
| 関連名称 | 10.3892/ijo.2013.1786 | |||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||
| タイトル | Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor‑κB activity in human oral cancer cells | |||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||
| その他のタイトル | BORTEZOMIB-ENHANCED RADIOSENSITIZATION IN HUMAN ORAL CANCER CELLS | |||||||||||||||||||||||||||||
| 著者 |
玉谷, 哲也
× 玉谷, 哲也× 髙丸, 菜都美
WEKO
411
× ハラ, カナエ
× キノウチ, マコト
× 栗林, 伸行× 大江, 剛× 内田, 大亮× 藤澤, 健司× 永井, 宏和× 宮本, 洋二
WEKO
1703
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| 内容記述 | Oral cancer cells have a significantly augmented nuclear factor-κB (NF-κB) activity and the inhibition of this activity suppresses tumor growth. Bortezomib is a proteasome inhibitor and a drug used for molecular-targeted therapy (targets NF-κB). In this study, we investigated whether bortezomib would be effective as an inhibitor of proliferation and a radiosensitizer for the treatment of oral cancer. We demonstrate that bortezomib inhibits NF-κB activity and cell proliferation. The combined treatment with bortezomib and radiation (RT) suppressed NF-κB activity and cell growth in vitro and in vivo compared with RT treatment alone. To investigate the mechanisms by which bortezomib suppresses tumor growth, the expression of signaling molecules downstream of NF-κB were examined by ELISA. The combined treatment significantly inhibited the radiation‑induced production of angiogenic factors and decreased the number of blood vessels in the tumor tissues. Although the expression of anti‑apoptotic proteins was upregulated by RT, bortezomib downregulated the RT-induced expression of these proteins. Moreover, the expression of cleaved poly(ADP‑ribose) polymerase in vitro and in vivo was enhanced by bortezomib, indicating that bortezomib inhibits tumor growth by inducing apoptosis. This study clearly demonstrates that bortezomib significantly inhibits tumor growth and that the combined treatment with bortezomib and RT results in a significant inhibition of tumor growth. The mechanisms underlying the inhibition of tumor growth by bortezomib include the suppression of angiogenesis and the induction of apoptosis. A novel molecular targeting therapy including bortezomib may be effective in the treatment of oral cancer by suppressing NF-κB activity. | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | nuclear factor-κB | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | bortezomib | |||||||||||||||||||||||||||||
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| 主題 | oral cancer | |||||||||||||||||||||||||||||
| 書誌情報 |
en : International Journal of Oncology 巻 42, 号 3, p. 935-944, 発行日 2013-01-22 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 10196439 | |||||||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 17912423 | |||||||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||
| 収録物識別子 | AA10992511 | |||||||||||||||||||||||||||||
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| 出版者 | Spandidos Publications | |||||||||||||||||||||||||||||
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| 識別子 | 259868 | |||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||
