| Item type |
文献 / Documents(1) |
| 公開日 |
2019-08-29 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.bbalip.2019.07.010 |
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|
関連名称 |
10.1016/j.bbalip.2019.07.010 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells |
| 著者 |
モリト, カツヤ
シミズ, リョウタ
キタムラ, ナホコ
Park, Si-Bum
キシノ, シゲノブ
オガワ, ジュン
福田, 達也
小暮, 健太朗
田中, 保
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| 抄録 |
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内容記述 |
Microorganisms in animal gut produce unusual fatty acids from the ingested diet. Two types of hydroxy fatty acids (HFAs), 10-hydroxy-cis-12-octadecenoic acid (HYA) and 10-hydroxy-octadecanoic acid (HYB), are linoleic acid (LA) metabolites produced by Lactobacillus plantarum. In this study, we investigated the metabolism of these HFAs in mammalian cells. When Chinese hamster ovary (CHO) cells were cultured with HYA, approximately 50% of the supplemented HYA disappeared from the dish within 24 hours. On the other hand, the amount of HYA that disappeared from the dish of peroxisome (PEX)-deficient CHO cells was lower than 20%. Significant amounts of C2- and C4-chain-shortened metabolites of HYA were detected in culture medium of HYA-supplemented CHO cells, but not in medium of PEX-deficient cells. These results suggested that peroxisomal β-oxidation is involved in the disappearance of HYA. The PEX-dependent disappearance was observed in the experiment with HYB, but not with LA. We also found that HYA treatment up-regulates peroxisomal β-oxidation activity of human gastric MKN74 cells and intestinal Caco-2 cells. These results indicate a possibility that HFAs produced from gut bacteria affect lipid metabolism of host via modulation of peroxisomal β-oxidation activity. |
| キーワード |
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|
主題 |
Peroxisomal β-oxidation |
| キーワード |
|
|
主題 |
Hydroxy fatty acid |
| キーワード |
|
|
主題 |
Linoleic acid |
| キーワード |
|
|
主題 |
Fatty acid metabolism |
| キーワード |
|
|
主題 |
Gut lactic acid bacteria |
| 書誌情報 |
en : Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
巻 1864,
号 11,
p. 1619-1628,
発行日 2019-07-24
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13881981 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11522965 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11300409 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
359915 |
| 言語 |
|
|
言語 |
eng |
bbalip_1864_11_1619.pdf (1.5 MB)
