| Item type |
文献 / Documents(1) |
| 公開日 |
2019-10-04 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.celrep.2015.10.012 |
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関連名称 |
10.1016/j.celrep.2015.10.012 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors |
| 著者 |
大東, いずみ
Zuklys, Saulius
サカタ, ミエ
Mayer, Carlos E.
ハマザキ, ヨウコ
ミナト, ナガヒロ
Hollander, Georg A.
高浜, 洋介
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| 抄録 |
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内容記述 |
Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-mapping analysis of cells that transcribe β5t, a cTEC trait expressed in bipotent progenitors, during a given period in mice. We show that, in adult mice, most mTECs are derived from progenitors that transcribe β5t during embryogenesis and the neonatal period up to 1 week of age. The contribution of adult β5t+ progenitors was minor even during injury-triggered regeneration. Our results further demonstrate that adult mTEC-restricted progenitors are derived from perinatal β5t+ progenitors. These results indicate that the adult thymic medullary epithelium is maintained and regenerated by mTEC-lineage cells that pass beyond the bipotent stage during early ontogeny. |
| 書誌情報 |
en : Cell Reports
巻 13,
号 7,
p. 1432-1443,
発行日 2015-11-05
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
22111247 |
| 出版者 |
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出版者 |
Elsevier |
| 権利情報 |
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|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
315884 |
| 言語 |
|
|
言語 |
eng |
celrep_13_7_1432.pdf (3.75 MB)
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