| Item type |
文献 / Documents(1) |
| 公開日 |
2019-11-05 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1038/hr.2015.74 |
|
|
関連名称 |
10.1038/hr.2015.74 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Bilirubin exerts pro-angiogenic property through Akt-eNOS-dependent pathway |
| タイトル別表記 |
|
|
その他のタイトル |
Bilirubin action on angiogenesis |
| 著者 |
池田, 康将
濱野, 裕章
サトウ, アキホ
堀ノ内, 裕也
(井澤)石澤, 有紀
木平, 孝高
石澤, 啓介
粟飯原, 賢一
土屋, 浩一郎
玉置, 俊晃
|
| 抄録 |
|
|
内容記述 |
Low serum bilirubin levels are associated with the risk of cardiovascular diseases including peripheral artery disease. Bilirubin is known to exert its property such as anti-oxidant effect or the enhancement of flow-mediated vasodilation, however, bilirubin action on angiogenesis remains unclear. To investigate the molecular mechanism of bilirubin on angiogenic effect, we first employed C57BL/6J mice with unilateral hindlimb ischemia surgery and divided the mice into two groups (vehicle-treated group and bilirubin treated group). The analysis of laser speckle blood flow demonstrated the enhancement of blood flow recovery in response to ischemia of mice with bilirubin treatment. The density of capillaries was significantly higher in ischemic adductor muscles of bilirubin-treated mice. The phosphorylated levels of endothelial nitric oxide synthesis (eNOS) and Akt were increased in ischemic skeletal muscles of mice with bilirubin treatment compared vehicle treatment. In in vitro experiments by using human aortic endothelial cells, bilirubin augmented eNOS and Akt phosphorylation, cell proliferation, cell migration and tube formation. These bilirubin actions on endothelial cell activation were inhibited by LY294002, a phosphatidylinositol 3-kinase inhibitor. In conclusion, bilirubin promotes angiogenesis through endothelial cells activation via Akt-eNOS-dependent manner. |
| キーワード |
|
|
主題 |
bilirubin |
| キーワード |
|
|
主題 |
angiogenesis |
| キーワード |
|
|
主題 |
endothelial cells |
| キーワード |
|
|
主題 |
eNOS |
| 書誌情報 |
en : Hypertension Research
巻 38,
号 11,
p. 733-740,
発行日 2015-07-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13484214 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09169636 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10847079 |
| 出版者 |
|
|
出版者 |
Springer Nature |
| 出版者 |
|
|
出版者 |
The Japanese Society of Hypertension |
| 備考 |
|
|
値 |
This is the Author's Accepted Manuscript of the following article: Bilirubin exerts pro-angiogenic property through Akt-eNOS-dependent pathway, Yasumasa Ikeda, Hirofumi Hamano, Akiho Satoh, Yuya Horinouchi, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Ken-ichi Aihara, Koichiro Tsuchiya & Toshiaki Tamaki, Hypertension Research 38, 733-740 (2015), which has been published in final form at https://doi.org/10.1038/hr.2015.74. |
| EID |
|
|
識別子 |
294522 |
| 言語 |
|
|
言語 |
eng |
hr_38_11_733.pdf (1010 KB)
