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Effect of low-intensity whole-body vibration on bone defect repair and associated vascularization in mice
https://tokushima-u.repo.nii.ac.jp/records/2006978
https://tokushima-u.repo.nii.ac.jp/records/2006978868eb1c1-383e-4a5e-8968-8980b8d5a2ad
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
mbec_55_12_2257.pdf (1.62 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2019-11-15 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1007/s11517-017-1664-4 | |||||||||||||||||
| 関連名称 | 10.1007/s11517-017-1664-4 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Effect of low-intensity whole-body vibration on bone defect repair and associated vascularization in mice | |||||||||||||||||
| 著者 |
松本, 健志
× 松本, 健志
WEKO
765
× ゴトウ, ダイチ
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| 抄録 | ||||||||||||||||||
| 内容記述 | Low-intensity whole-body vibration (LIWBV) may stimulate bone healing, but the involvement of vascular ingrowth, which is essential for bone regeneration, has not been well examined. We thus investigated the LIWBV effect on vascularization during early-stage bone healing. Mice aged 13 weeks were subjected to cortical drilling on tibial bone. Two days after surgery (day 0), mice were exposed daily to sine-wave LIWBV at 30 Hz and 0.1 g peak-to-peak acceleration for 20 min/day (Vib) or were sham-treated (sham). Following vascular casting with a zirconium-based contrast agent on days 6, 9, or 12 and sacrifice, vascular and bone images were obtained by K-edge subtraction micro-CT using synchrotron lights. Bone regeneration advanced more in the Vib group from days 9 to 12. The vascular volume fraction decreased from days 6 to 9 in both groups; however, from days 9 to 12, it was increased in shams, while it stabilized in the Vib group. The vascular volume fraction tended to be or was smaller in the Vib group on days 6 and 12. The vessel number density was higher on day 9 but lower on day 12 in the Vib group. These results suggest that the LIWBV-promoted bone repair is associated with the modulation of vascularization, but additional studies are needed to determine the causality of this association. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Low-magnitude vibration | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Cortical bone defect | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Vascular ingrowth | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Synchrotron radiation | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | K-edge subtraction | |||||||||||||||||
| 書誌情報 |
en : Medical & Biological Engineering & Computing 巻 55, 号 12, p. 2257-2266, 発行日 2017-06-29 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 01400118 | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 17410444 | |||||||||||||||||
| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA00726781 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Springer Berlin Heidelberg | |||||||||||||||||
| 備考 | ||||||||||||||||||
| 値 | This is a post-peer-review, pre-copyedit version of an article published in Medical & Biological Engineering & Computing. The final authenticated version is available online at: https://doi.org/10.1007/s11517-017-1664-4. | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 331649 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
