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Effect of Concurrent Use of Whole-Body Vibration and Parathyroid Hormone on Bone Structure and Material Properties of Ovariectomized Mice
https://tokushima-u.repo.nii.ac.jp/records/2006979
https://tokushima-u.repo.nii.ac.jp/records/20069794fc10e89-9b90-456d-a0f6-de293e715206
| 名前 / ファイル | ライセンス | アクション |
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cti_98_5_520.pdf (1.1 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2019-11-15 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1007/s00223-015-0104-4 | |||||||||||||||||||||||
| 関連名称 | 10.1007/s00223-015-0104-4 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Effect of Concurrent Use of Whole-Body Vibration and Parathyroid Hormone on Bone Structure and Material Properties of Ovariectomized Mice | |||||||||||||||||||||||
| 著者 |
松本, 健志
× 松本, 健志
WEKO
765
× イタモチ, シンヤ
× ハシモト, ヨシヒロ
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| 内容記述 | This study was designed to determine the effectiveness of whole-body vibration (WBV) and intermittent parathyroid hormone (iPTH) in combination against estrogen deficiency-induced osteoporosis. Female C57BL/6J mice were bilaterally ovariectomized (OVX, n = 40) or sham-operated (sham-OVX, n = 8) at 9 weeks of age. Two weeks later, the OVX mice were randomly divided into four groups (n = 10 each): the control group (c-OVX) and groups treated with iPTH (p-OVX), WBV (w-OVX) and both (pw-OVX). The p-OVX and pw-OVX groups were given human PTH (1–34) at a dose of 30 μg/kg/day. The w-OVX and pw-OVX groups were exposed to WBV at an acceleration of 0.3 g and 45 Hz for 20 min/day. All mice were euthanized after the 18-day treatment, and the left tibiae were harvested. The proximal metaphyseal region was μCT-scanned, and its cortical bone cross-section was analyzed by Fourier transform infrared microspectroscopy and nanoindentation testing. A single application of iPTH or WBV to OVX mice had no effect on bone structure or material properties of cortical bone, which were compromised in comparison with those in sham-OVX mice. The combination of iPTH and WBV improved trabecular bone volume, thickness and connectivity in OVX mice. Although the combined treatment failed to improve cortical bone structure, its mineral maturity and hardness restored to the levels observed in sham-OVX mice. There was no evidence of interaction between the two treatments, and the combined effects seemed to be additive. These results suggest combining WBV with iPTH has potential for treating postmenopausal osteoporosis. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Postmenopausal osteoporosis | |||||||||||||||||||||||
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| 主題 | Low-magnitude high-frequency vibration | |||||||||||||||||||||||
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| 主題 | Parathyroid hormone | |||||||||||||||||||||||
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| 主題 | Microcomputed tomography | |||||||||||||||||||||||
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| 主題 | micro-computed tomography | |||||||||||||||||||||||
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| 主題 | Infrared microspectroscopy | |||||||||||||||||||||||
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| 主題 | Nanoindentation testing | |||||||||||||||||||||||
| 書誌情報 |
en : Calcified Tissue International 巻 98, 号 5, p. 520-529, 発行日 2016-01-08 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 0171967X | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 14320827 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00141085 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Springer US | |||||||||||||||||||||||
| 備考 | ||||||||||||||||||||||||
| 値 | This is a post-peer-review, pre-copyedit version of an article published in Calcified Tissue International. The final authenticated version is available online at: https://doi.org/10.1007/s00223-015-0104-4. | |||||||||||||||||||||||
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| 識別子 | 312305 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
