WEKO3
アイテム
In vivo monitoring of bone microstructure by propagation-based phase-contrast computed tomography using monochromatic synchrotron light
https://tokushima-u.repo.nii.ac.jp/records/2006980
https://tokushima-u.repo.nii.ac.jp/records/200698089083a2c-9250-4b75-953e-8b8afd160d0c
| 名前 / ファイル | ライセンス | アクション |
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labinvest_100_1_72.pdf (910 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2019-11-15 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41374-019-0337-3 | |||||||||||||||||||||||
| 関連名称 | 10.1038/s41374-019-0337-3 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | In vivo monitoring of bone microstructure by propagation-based phase-contrast computed tomography using monochromatic synchrotron light | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | In vivo monitoring of bone microstructure by propagation-based phase-contrast CT using monochromatic synchrotron light | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | In-vivo bone CT based on phase contrast | |||||||||||||||||||||||
| 著者 |
松本, 健志
× 松本, 健志
WEKO
765
× シミズ, リョウタ
× ウエスギ, ケンタロウ
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Hard X-ray phase-contrast imaging is sensitive to density variation in objects and shows a great dose advantage for in vivo observation over absorption-contrast imaging. We examined the capability of propagation-based phase-contrast tomography (PB-PCT) with single-distance phase retrieval for tracking of bone structure and mineral changes using monochromatic synchrotron light. Female mice underwent ovariectomy and drill-hole surgery in the right tibial diaphysis and were divided into two groups: OVX and OVX-E (n = 6 each); the latter group was treated with intraperitoneal administration of 14,15-epoxyeicosatrienoic acid (14,15-EET) for promoting bone repair. Age-matched mice subjected to sham ovariectomy and drill-hole surgery (Sham) were also prepared (n = 6). In vivo CT scans of the drilled defect were acquired 3, 7, and 11 days after surgery, and tomographic images were matched by three-dimensional registration between successive time points for monitoring the process of defect filling. Additionally, using absorption-contrast CT as the reference method, the validity of PB-PCT was evaluated in one mouse by comparing images of tibial metaphyseal bone between the two methods in terms of bone geometry as well as the measure of mineralization. Although phase retrieval is strictly valid only for single-material objects, PB-PCT, with its lower radiation dose, could provide a depiction of bone structure similar to that from absorption-contrast CT. There was a significant correlation of linear absorption coefficients between the two methods, indicating the possibility of a rough estimate of the measure of mineralization by PB-PCT. Indeed, delayed bone regeneration (OVX vs. Sham) and the efficacy of 14,15-EET for improving osteoporotic bone repair (OVX-E vs. OVX) could be detected in both bone volume and mineralization by PB-PCT. Thus, in combination with single-distance phase retrieval, PB-PCT would have great potential for providing a valuable tool to track changes in bone structure and mineralization, and for evaluating the effects of therapeutic interventions as well. | |||||||||||||||||||||||
| 書誌情報 |
en : Laboratory Investigation 巻 100, 号 1, p. 72-83, 発行日 2019-10-22 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 15300307 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 00236837 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA12189985 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00713961 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||||||||
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| 識別子 | 362094 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
