| Item type |
文献 / Documents(1) |
| 公開日 |
2019-11-29 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0216416 |
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関連名称 |
10.1371/journal.pone.0216416 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Circulating osteocalcin as a bone-derived hormone is inversely correlated with body fat in patients with type 1 diabetes |
| タイトル別表記 |
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その他のタイトル |
Osteocalcin and body fat in type 1 diabetes |
| 著者 |
髙士, 祐一
イシヅ, マサシ
森, 博康
ミヤシタ, カズユキ
サカモト, フミエ
カタカミ, ナオト
マツオカ, タカアキ
ヤスダ, テツユキ
橋田, 誠一
松久, 宗英
黒田, 暁生
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| 抄録 |
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内容記述 |
The objective of the present study was to investigate the correlations between serum under-carboxylated osteocalcin (ucOC) or osteocalcin (OC) concentrations and %body fat, serum adiponectin and free-testosterone concentration, muscle strength and dose of exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult patients with childhood-onset type 1 diabetes. All participants were receiving insulin replacement therapy. The correlations between logarithmic serum ucOC or OC concentrations and each parameter were examined. Serum ucOC and OC concentrations were inversely correlated with% body fat (r = -0.319, P = 0.007; r = -0.321, P = 0.006, respectively). Furthermore, multiple linear regression analyses were performed to determine whether or not serum ucOC or OC concentrations were factors associated with %body fat. Serum ucOC and OC concentrations remained significant factors even after adjusting for gender, HbA1c, body weight-adjusted total daily dose of insulin and duration of diabetes (β = -0.260, P = 0.027; β = -0.254, P = 0.031, respectively). However, serum ucOC and OC concentrations were not correlated with serum adiponectin or free-testosterone concentrations, muscle strength or dose of exogenous insulin. In conclusion, our study demonstrates the inverse correlation between serum ucOC or OC concentrations and body fat in patients with type 1 diabetes. |
| 書誌情報 |
en : PLOS ONE
巻 14,
号 5,
p. e0216416,
発行日 2019-05-03
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
19326203 |
| 出版者 |
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出版者 |
PLOS |
| 権利情報 |
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|
権利情報 |
© 2019 Takashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
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|
識別子 |
352297 |
| 言語 |
|
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言語 |
eng |
pone_14_5_e0216416.pdf (636 KB)
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