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Enhancement of antioxidative activity of astaxanthin by combination with an antioxidant capable of forming intermolecular interactions
https://tokushima-u.repo.nii.ac.jp/records/2007056
https://tokushima-u.repo.nii.ac.jp/records/2007056d3654bcb-2030-4a3a-a655-e016029d5edc
| 名前 / ファイル | ライセンス | アクション |
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frr_54_11-12_818.pdf (1.03 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2020-01-10 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1080/10715762.2019.1693042 | |||||||||||||||||||||||
| 関連名称 | 10.1080/10715762.2019.1693042 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Enhancement of antioxidative activity of astaxanthin by combination with an antioxidant capable of forming intermolecular interactions | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | Capsaicin enhances astaxanthin action in liposomes | |||||||||||||||||||||||
| 著者 |
福田, 達也
× 福田, 達也× ヒライ, ショウタ
× 吉田, 達貞× マオカ, タカシ
× 小暮, 健太朗
WEKO
1139
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| 内容記述 | We previously demonstrated that co-encapsulation of the potent antioxidant astaxanthin (Asx) and tocotrienols into liposomes results in synergistically higher antioxidative activity than the calculated additive activity of each individual antioxidant-containing liposome, due to intermolecular interactions between terminal ring moieties of the two antioxidants and the polyene chain and the triene moiety. We reported that intermolecular interactions depend on the stereochemistry of Asx, and change the electronic state of the Asx polyene moiety. Based on these findings, we hypothesized that antioxidants that interact with Asx at the terminal ring and polyene moieties may enhance the antioxidative activity. Herein, we selected two candidate antioxidants, capsaicin (Cap) and resveratrol, based on their structures, in which the compounds exhibit similar characteristics to tocotrienols. We evaluated the antioxidative capacities of liposomes co-encapsulating Asx and the selected candidates. Based on hydroxyl radical scavenging activity, Cap was found to synergistically enhance the antioxidative activity of Asx at an optimal Asx/Cap ratio. Intermolecular interactions between Asx and Cap are necessary for the synergistic effect, and the Asx stereoisomer 3R,3’R-form (Asx-R) was predicted to most potently interact. Liposomes co-encapsulating Asx-R and Cap exhibited clear synergistic antioxidative activity at an optimal ratio, whereas liposomes co-encapsulating the other Asx stereoisomer and Cap did not demonstrate such activity. Computational chemistry analysis showed that changes in the electronic state of the polyene moiety of Asx-R are crucial for the synergistic activity. These results suggest that antioxidants that can change the electronic state of Asx via intermolecular interactions may enhance the function of Asx. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Antioxidants | |||||||||||||||||||||||
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| 主題 | Astaxanthin | |||||||||||||||||||||||
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| 主題 | Liposomes | |||||||||||||||||||||||
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| 主題 | Capsaicin | |||||||||||||||||||||||
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| 主題 | Intermolecular interactions | |||||||||||||||||||||||
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| 主題 | Stereochemistry | |||||||||||||||||||||||
| 書誌情報 |
en : Free Radical Research 巻 54, 号 11-12, p. 818-828, 発行日 2019-11-13 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 10715762 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 10292470 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11001805 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Taylor & Francis | |||||||||||||||||||||||
| 備考 | ||||||||||||||||||||||||
| 値 | This is an Accepted Manuscript of an article published by Taylor & Francis in Free Radical Research on 13/11/2019, available online: http://www.tandfonline.com/10.1080/10715762.2019.1693042. | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 361354 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
