| Item type |
文献 / Documents(1) |
| 公開日 |
2020-01-24 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fneur.2019.01258 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3389/fneur.2019.01258 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Intrastriatal Memantine Infusion Dampens Levodopa-Induced Dyskinesia and Motor Deficits in a Mouse Model of Hemiparkinsonism |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Intrastriatal Memantine Infusion |
|
言語 |
en |
| 著者 |
オガワ, マサトシ
Zhou, Yu
ツジ, リョウスケ
笠原, 二郎
後藤, 惠
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Although the administration of dopamine precursor levodopa remains as the mainstay for the treatment of Parkinson’s disease, long-term exposure to levodopa often causes a disabling complication, referred to as levodopa-induced dyskinesias. Therefore, the development of new therapeutic interventions to dampen levodopa-induced dyskinesias and parkinsonian motor deficits is needed in the treatment of Parkinson’s disease. Intracerebral brain infusion has the merit of being able to specifically deliver any drug into any brain part. By using an intracerebral infusion system equipped with implantable, programmable, and refillable pumps, we show herein that continuous intrastriatal administration of memantine (MMT), which is a non-competitive N-methyl-D-aspartate receptor antagonist, attenuates levodopa-induced dyskinesias and parkinsonian signs in 6-hydroxydopamine-lesioned hemiparkinsonian mice that received daily levodopa treatment. Corroborating the general thought that overactivation of the striatal N-methyl-D-aspartate receptor function might generate levodopa-induced dyskinesias and parkinsonism, our results suggest that a continuous intrastriatal MMT infusion can be beneficial for the management of Parkinson’s disease with levodopa-induced dyskinesias. Our study also provides indications for the prototypic use of pharmacological deep-brain modulation through intracerebral infusion systems for treating medically intractable movement disorders. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
intracerebral brain infusion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
levodopa-induced dyskinesia |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
memantine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
N-methyl-D-aspartate receptor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Parkinson’s disease |
| 書誌情報 |
en : Frontiers in Neurology
巻 10,
p. 1258,
発行日 2019-12-05
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16642295 |
| 出版者 |
|
|
出版者 |
Frontiers |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2019 Ogawa, Zhou, Tsuji, Kasahara and Goto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
370522 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
fneur_10_1258.pdf (754 KB)
