| Item type |
文献 / Documents(1) |
| 公開日 |
2020-02-05 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1074/jbc.M200186200 |
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言語 |
ja |
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関連名称 |
10.1074/jbc.M200186200 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Loss of the Peroxisome Proliferation-activated Receptor gamma (PPARγ) Does Not Affect Mammary Development and Propensity for Tumor Formation but Leads to Reduced Fertility |
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言語 |
en |
| タイトル別表記 |
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その他のタイトル |
PPARγ Loss Leads to Reduced Fertility |
|
言語 |
en |
| 著者 |
Cui, Yongzhi
三好, 圭子
Claudio, Estefania
Siebenlist, Ulrich K.
Gonzalez, Frank J.
Flaws, Jodi
Wagner, Kay-Uwe
Hennighausen, Lothar
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The peroxisome proliferation-activated receptor gamma (PPARγ) is expressed in many cell types including mammary epithelium, ovary, macrophages, and B- and T-cells. PPARγ has an anti-proliferative effect in pre-adipocytes and mammary epithelial cells, and treatment with its ligands reduced the progression of carcinogen-induced mammary tumors in mice. Because PPARγ-null mice die in utero it has not been possible to study its role in development and tumorigenesis in vivo. To investigate whether PPARγ is required for the establishment and physiology of different cell types, a cell-specific deletion of the gene was carried out in mice using the Cre-loxP recombination system. We deleted the PPARγ gene in mammary epithelium using WAP-Cre transgenic mice and in epithelial cells, B- and T-cells, and ovary cells using MMTV-Cre mice. The presence of PPARγ was not required for functional development of the mammary gland during pregnancy and for the establishment of B- and T-cells. In addition, no increase in mammary tumors was observed. However, loss of the PPARγ gene in oocytes and granulosa cells resulted in impaired fertility. These mice have normal populations of follicles, they ovulate and develop corpora lutea. Although progesterone levels are decreased and implantation rates are reduced, the exact cause of the impaired fertility remains to be determined. |
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言語 |
en |
| 書誌情報 |
en : Journal of Biological Chemistry
巻 277,
号 20,
p. 17830-17835,
発行日 2002-03-07
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1083351X |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA1202441X |
| 出版者 |
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出版者 |
The American Society for Biochemistry and Molecular Biology |
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言語 |
en |
| 備考 |
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言語 |
ja |
|
値 |
This research was originally published in the Journal of Biological Chemistry. Yongzhi Cui, Keiko Miyoshi, Estefania Claudio, Ulrich K. Siebenlist, Frank J. Gonzalez, Jodi Flaws, Kay-Uwe Wagner and Lothar Hennighausen. Loss of the Peroxisome Proliferation-activated Receptor gamma (PPARγ) Does Not Affect Mammary Development and Propensity for Tumor Formation but Leads to Reduced Fertility. J. Biol. Chem. 2002; 277(20):17830-17835. |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
© The American Society for Biochemistry and Molecular Biology |
| EID |
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識別子 |
89760 |
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識別子タイプ |
URI |
| 言語 |
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言語 |
eng |
jbc_277_20_17830.pdf (642 KB)
