| Item type |
文献 / Documents(1) |
| 公開日 |
2020-02-27 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1172/jci.insight.88646 |
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|
言語 |
ja |
|
|
関連名称 |
10.1172/jci.insight.88646 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells |
|
言語 |
en |
| 著者 |
増田, 真志
ミヤザキ アンザイ, シノブ
| ja |
ミヤザキ アンザイ, シノブ
|
| ja-Kana |
ミヤザキ アンザイ, シノブ
|
| en |
Miyazaki-Anzai, Shinobu
|
Search repository
Keenan, Audrey L.
シオザキ, ユウジ
オカムラ, カヨ
Chick, Wallace S.
Williams, Kristina
Zhao, Xiaoyun
Rahman, Shaikh Mizanoor
Tintut, Yin
Adams, Christopher M.
ミヤザキ, マコト
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Emerging evidence indicates that upregulation of the ER stress–induced pro-osteogenic transcription factor ATF4 plays an important role in vascular calcification, a common complication in patients with aging, diabetes, and chronic kidney disease (CKD). In this study, we demonstrated the pathophysiological role of ATF4 in vascular calcification using global Atf4 KO, smooth muscle cell–specific (SMC-specific) Atf4 KO, and transgenic (TG) mouse models. Reduced expression of ATF4 in global ATF4-haplodeficient and SMC-specific Atf4 KO mice reduced medial and atherosclerotic calcification under normal kidney and CKD conditions. In contrast, increased expression of ATF4 in SMC-specific Atf4 TG mice caused severe medial and atherosclerotic calcification. We further demonstrated that ATF4 transcriptionally upregulates the expression of type III sodium-dependent phosphate cotransporters (PiT1 and PiT2) by interacting with C/EBPβ. These results demonstrate that the ER stress effector ATF4 plays a critical role in the pathogenesis of vascular calcification through increased phosphate uptake in vascular SMCs. |
|
言語 |
en |
| 書誌情報 |
en : JCI Insight
巻 1,
号 18,
p. e88646,
発行日 2016-11-03
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
23793708 |
| 出版者 |
|
|
出版者 |
American Society for Clinical Investigation |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Open Access Journal |
| EID |
|
|
識別子 |
328628 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jci_1_18_e88646.pdf (1.04 MB)
