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ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols
https://tokushima-u.repo.nii.ac.jp/records/2007301
https://tokushima-u.repo.nii.ac.jp/records/2007301dd45eda5-b992-47c8-9edb-c61fd8c85925
| 名前 / ファイル | ライセンス | アクション |
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pone_13_9_e0204229.pdf (2.92 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2020-03-18 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0204229 | |||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0204229 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | ATP/P2X7R signaling as a target of natural polyphenols | |||||||||||||||||||||||
| 著者 |
ヌカ, エリカ
× ヌカ, エリカ
× 大西, 康太
× 寺尾, 純二
WEKO
170
× 河合, 慶親 |
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| 内容記述 | Innate immune cells, such as macrophages, respond to pathogen-associated molecular patterns, such as a lipopolysaccharide (LPS), to secrete various inflammatory mediators. Recent studies have suggested that damage-associated molecular patterns (DAMPs), released extracellularly from damaged or immune cells, also play a role in the activation of inflammatory responses. In this study, to prevent excess inflammation, we focused on DAMPs-mediated signaling that promotes LPS-stimulated inflammatory responses, especially adenosine 5’-triphosphate (ATP)-triggered signaling through the ionotropic purinergic receptor 7 (P2X7R), as a potential new anti-inflammatory target of natural polyphenols. We focused on the phenomenon that ATP accelerates the production of inflammatory mediators, such as nitric oxide, in LPS-stimulated J774.1 mouse macrophages. Using an siRNA-mediated knockdown and specific antagonist, it was found that the ATP-induced enhanced inflammatory responses were mediated through P2X7R. We then screened 42 polyphenols for inhibiting the ATP/P2X7R-induced calcium influx, and found that several polyphenols exhibited significant inhibitory effects. Especially, a flavonoid baicalein significantly inhibited ATP-induced inflammation, including interleukin-1β secretion, through inhibition of the ATP/P2X7R signaling. These findings suggest that ATP/P2X7R signaling plays an important role in excess inflammatory responses and could be a potential anti-inflammatory target of natural polyphenolic compounds. | |||||||||||||||||||||||
| 書誌情報 |
en : PLOS ONE 巻 13, 号 9, p. e0204229, 発行日 2018-09-24 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||||
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| 出版者 | PLOS | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | © 2018 Nuka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 357162 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
